Can a simpler chemo schedule tame colorectal cancer with fewer side effects?

This trial tests whether giving the chemotherapy drugs raltitrexed and oxaliplatin every two weeks is as effective and less toxic than the standard every-three-week schedule in people with metastatic colorectal cancer who have not had prior chemotherapy. Some participants also receive the targeted drug bevacizumab. The study measures drug levels in the blood, tumor response, side effects, and survival to see if the biweekly approach could be a better option.