New hope for tough tumors: Half-Matched bone marrow transplant trial

NCT ID NCT01804634

Recruiting now Disease control Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a bone marrow transplant from a half-matched family donor for people with high-risk solid tumors that have come back or not responded to treatment. Participants receive mild chemotherapy and radiation before the transplant, along with drugs to prevent rejection. The goal is to see if this approach is safe and can help control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bone marrow transplant from a half-matched related donor
What this could lead to: If successful, this could offer a new treatment option for patients with hard-to-treat solid tumors that have not responded to standard therapies.
What could go wrong: This is an early phase II trial with only 60 participants, so results may not apply to everyone. The procedure carries serious risks, including graft-versus-host disease and infection.

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Conditions

The condition(s) this trial relates to.

desmoplastic small round cell tumor Ewing sarcoma ganglioneuroblastoma hepatoblastoma metastatic malignant neoplasm neuroblastoma osteosarcoma rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY AND/OR RELAPSED METASTATIC SOLID TUMORS

Contacts and locations

Locations

Albert Einstein College of Medicine, Children's Hospital at Montefiore
RECRUITING

The Bronx, New York, 10467, United States
New York Medical Center/ Maria Fareri Children's Hospital
RECRUITING

Valhalla, New York, 10595, United States
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
RECRUITING

Baltimore, Maryland, 21231, United States

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