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New drug cocktail aims to keep childhood cancers at bay

NCT ID NCT04469530

Recruiting now Disease control Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether a year-long maintenance regimen of sirolimus (rapamycin) plus low-dose oral chemotherapy and celecoxib can improve 2-year survival without cancer progression in children with high-risk solid tumors. About 55 children and young adults (ages 1–30) who have completed standard therapy will receive the drug combination. The results will be compared to historical data from similar patients who only had observation after standard treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
sirolimus (rapamycin) and low-dose chemotherapy (metronomic chemotherapy) with celecoxib
What this could lead to
If successful, this maintenance regimen could help keep high-risk solid tumors from returning in children, improving long-term survival rates.
What could go wrong
This is a phase 2 trial with only 55 participants, comparing results to past patients rather than a control group. The combination may cause side effects and might not improve survival.

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Conditions

The condition(s) this trial relates to.

desmoplastic small round cell tumor Ewing sarcoma localized osteosarcoma neoplasm osteosarcoma rhabdoid tumor rhabdomyosarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOR

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Aflac Cancer & Blood Disorders Centers

    RECRUITING

    Atlanta, Georgia, 30329, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Healthcare of Atlanta

    RECRUITING

    Atlanta, Georgia, 30329, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC)

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Children's Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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