Can a radioactive injection target bone tumors? a Dose-Finding trial aims to find out
NCT ID NCT06008483
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This early-stage trial is testing an experimental drug called CycloSam (153-Sm-DOTMP), a radioactive compound that delivers radiation directly to bone tumors when injected. The study aims to find the safest dose in people aged 15 to 75 with solid tumors that have spread to the bone, including certain cancers like prostate, breast, lung, and sarcomas. Participants receive two doses, and researchers monitor for side effects and tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a radiopharmaceutical called CycloSam (153-Sm-DOTMP) that delivers radiation directly to bone tumors when injected
- What this could lead to
- If successful, this could lead to a new treatment option for people with solid tumors that have spread to the bone, potentially slowing tumor growth.
- What could go wrong
- This is a very early Phase 1 trial with only 5 participants, focused on finding a safe dose. It is not designed to prove effectiveness, and there is a risk of serious side effects from radiation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinical Trial Site
Chicago, Illinois, 60616, United States
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Clinical Trial Site
Columbia, Missouri, 65212, United States
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Clinical Trial Site
New Brunswick, New Jersey, 08901, United States
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Clinical Trial Site
Houston, Texas, 77024, United States
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