Radioactive antibody targets rare childhood cancer
NCT ID NCT04022213
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This phase 2 trial tests a combination treatment for desmoplastic small round cell tumor (DSRCT), a rare cancer that often spreads in the abdomen. Participants receive a single dose of a radioactive antibody called 131I-omburtamab directly into the abdomen, followed by targeted radiation to the whole abdomen. The goal is to see if this approach can delay or prevent the cancer from coming back after surgery and chemotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a radioactive antibody called 131I-omburtamab given through a catheter into the abdomen, plus external beam radiation
- What this could lead to
- If it works, this combination could help prevent or delay the return of this rare cancer after surgery and chemotherapy.
- What could go wrong
- This is a small, early-phase trial with only 31 participants, so results may not apply widely. The treatment involves radiation and may cause side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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