New combo therapy aims to shrink rectal tumors before surgery
NCT ID NCT07281768
First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 5 times
Summary
This phase 2 trial will test whether adding immunotherapy drugs (cemiplimab alone or with fianlimab or REGN7075) to standard chemotherapy (capecitabine and oxaliplatin) can completely eliminate tumors in patients with locally advanced rectal cancer before surgery. The study plans to enroll 66 adults with a specific type of rectal cancer (MSS) who have not had prior treatment. The main goal is to see how many patients have no cancer cells left in their surgical specimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Capecitabine, Oxaliplatin, Cemiplimab, Fianlimab, REGN7075
- What this could lead to
- If successful, this could offer a new treatment option that shrinks rectal tumors before surgery, potentially improving outcomes and reducing the need for more aggressive treatments.
- What could go wrong
- This is an early phase 2 trial with only 66 participants, so results may not apply to everyone. Combining drugs can increase side effects, and the added benefit of the immunotherapy drugs is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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- Rearranging the treatment timeline: could a new sequence of chemo and radiation spare rectal cancer patients from major surgery?
- Rectal cancer: could a 'Watch and Wait' strategy spare patients from major surgery?
- Blood test and CT combo may spare rectal cancer patients a second surgery