Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This study is testing a specialized surgery for adults with certain pancreatic or bile duct tumors who are at high risk for dangerous leaks after standard surgery. The procedure removes the entire pancreas to eliminate the tumor, then immediately transplants the patient's own ins…

This early-stage study is testing a new combination treatment for people with advanced fibrolamellar hepatocellular carcinoma (FLC), a rare type of liver cancer. The treatment combines a personalized vaccine that targets a specific cancer marker with three other drugs designed to…

This study tests whether adding newer immunotherapy drugs to standard chemotherapy before surgery works better for rectal cancer that hasn't spread. Researchers will compare three different drug combinations in 66 patients to see which helps shrink tumors most effectively with ac…

This study is testing whether a new DNA vaccine called pBI-11 can help the body's immune system clear persistent HPV16 or HPV18 infections in women. These specific HPV types are known to cause most cervical cancers. The trial will enroll 48 women who will receive either the vacci…

This early-stage study is testing whether adding an oral drug called momelotinib to a standard injected therapy (azacitidine) is safe and effective for people with certain rare, overlapping blood cancers. The goal is to better control the disease, reduce symptoms like an enlarged…

This early study is testing if a pill called ruxolitinib can safely treat a severe, life-threatening immune system overreaction that sometimes happens after CAR-T cell therapy for cancer. The study will enroll about 16 adults who develop this condition, called IEC-HS, to see if t…

This is a first-in-human study to test the safety of a new imaging drug called [18F]DK222. The drug is designed to stick to a specific protein (PD-L1) on cancer cells, potentially making tumors show up more clearly on a PET/CT scan. The trial will enroll 6 adults with lung or bla…

This study is testing whether virtual music therapy is a practical way to help improve quality of life for people recently diagnosed with a serious brain cancer called glioblastoma. Researchers will enroll 35 participants who are receiving standard cancer treatment. Half will hav…