Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This study tests an experimental DNA vaccine called pBI-11 in 48 women with persistent HPV16 or HPV18 infections. The vaccine is designed to boost the immune system to clear these high-risk viruses, which can cause cervical cancer. Participants will receive either the vaccine or …

This study tests whether adding immunotherapy drugs (cemiplimab alone or with fianlimab or REGN7075) to standard chemotherapy can improve outcomes for people with locally advanced rectal cancer before they have surgery. About 66 adults with a specific type of rectal cancer (MSS) …

This study looks at a two-part surgery for people with certain pancreatic tumors who are at high risk for leaks after standard surgery. First, the whole pancreas is removed to eliminate the tumor. Then, the patient's own insulin-producing cells are put back into the liver to help…

This study tests a new drug (DCSZ11) combined with short radiation and chemotherapy for people with a high-risk type of rectal cancer that hasn't spread. The goal is to shrink or eliminate the tumor before surgery, potentially avoiding the need for a permanent colostomy. About 30…

This early study tests the drug ruxolitinib in 16 adults who develop a severe inflammatory condition called IEC-HS after CAR-T therapy. The goal is to see if the drug is safe and can control the inflammation. Participants take the drug twice daily for up to 8 weeks. This is a sma…

This early-phase study tests a personalized vaccine plus three other drugs in 27 people with advanced fibrolamellar liver cancer that has worsened despite prior immunotherapy. The goal is to see if the combination is safe and shrinks tumors. Participants must have a specific gene…

This study tests whether adding a targeted radioactive drug (177Lu-PSMA-617) to standard radiation can safely allow men with high-risk prostate cancer to take hormone therapy for only 6 months instead of the usual 24 months. The goal is to maintain cancer control while reducing s…

This study is testing whether a new type of MRI scan can help doctors more precisely target radiation therapy for glioblastoma, an aggressive brain cancer. The scan, called APT imaging, aims to identify the most active and dangerous parts of the tumor. If successful, this could a…

This study looks at whether virtual music therapy is possible for people newly diagnosed with glioblastoma, a serious brain cancer, after they finish standard treatment. About 35 people will take part in online music sessions and fill out surveys. The goal is to see if this appro…