New surgery aims to cut pancreatic leak and diabetes risk

NCT ID NCT07360119

Not yet recruiting Disease control Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests a surgery called total pancreatectomy with islet autotransplantation (TPIAT) in 30 adults with certain pancreatic tumors who are at high risk for a dangerous leak after standard surgery. The procedure removes the entire pancreas and transplants the insulin-making cells into the liver to help prevent severe diabetes. Researchers will track complications, hospital stay length, and how well the transplanted cells work to see if this approach is safe and feasible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Total pancreatectomy with islet autotransplantation (TPIAT) – a surgery to remove the pancreas and transplant its insulin-making cells into the liver
What this could lead to: If successful, this approach could offer a safer surgical option for patients with certain pancreatic tumors, reducing the chance of a dangerous pancreatic leak and lowering the risk of severe diabetes after surgery.
What could go wrong: This is a very early, small study (30 people) with no comparison group, so results may not apply broadly. The surgery is major and carries risks like infection, bleeding, and the transplanted cells may not work well enough to prevent diabetes.

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Conditions

The condition(s) this trial relates to.

distal biliary tract carcinoma duodenal adenocarcinoma gastrointestinal stromal tumor malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm pancreatic mucinous-cystic neoplasm pancreatic neoplasm pancreatic neuroendocrine neoplasm periampullary adenocarcinoma serous cystadenoma small intestine leiomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC CANCER PERIAMPULLARY NEOPLASMS

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