New vaccine aims to reverse HPV-Linked cervical changes without surgery
NCT ID NCT07454915
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a DNA vaccine called PVX4 in 138 women with HPV16-related high-grade cervical dysplasia (CIN2/3). The vaccine is given as a shot with a small electrical pulse to help it enter cells. The goal is to see if it can clear the virus and make abnormal cervical tissue return to normal within 6 months, potentially avoiding the need for surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PVX4 (pBI-4 DNA vaccine delivered via electroporation)
- What this could lead to
- If successful, this could offer a non-surgical treatment to clear HPV16 and reverse early cervical changes, potentially preventing cervical cancer.
- What could go wrong
- This is a mid-stage trial with only 138 participants. The vaccine may not work better than placebo, and long-term effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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China Medical University Hospital
NOT_YET_RECRUITINGTaichung, Taiwan, 40447, Taiwan
Contact
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Kaohsiung Chang Gung Memorial Hospital
NOT_YET_RECRUITINGKaohsiung, Taiwan, 83301, Taiwan
Contact
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Linkou Chang Gung Memorial Hospital
RECRUITINGTaoyuan, Taiwan, 33305, Taiwan
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MacKay Memorial Hospital
NOT_YET_RECRUITINGTaipei, Taiwan, 10449, Taiwan
Contact
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Montefiore Medical Center
NOT_YET_RECRUITINGThe Bronx, New York, 10467, United States
Contact
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National Cheng Kung University Hospital
NOT_YET_RECRUITINGTainan, Taiwan, 70403, Taiwan
Contact
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National Taiwan University Hospital
NOT_YET_RECRUITINGTaipei, Taiwan, 100225, Taiwan
Contact
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Taichung Veterans General Hospital
NOT_YET_RECRUITINGTaichung, Taiwan, 40705, Taiwan
Contact
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Taipei Medical University Hospital
NOT_YET_RECRUITINGTaipei, Taiwan, 11031, Taiwan
Contact
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Taipei Veterans General Hospital
NOT_YET_RECRUITINGTaipei, Taiwan, 11217, Taiwan
Contact
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