Could a vaccine wipe out HPV and prevent cervical cancer?

NCT ID NCT07454915

First seen Mar 09, 2026 · Last updated Apr 28, 2026 · Updated 4 times

Summary

This study tests a new vaccine called PVX4 in 138 women with high-grade cervical changes (CIN2/3) caused by HPV16. The vaccine aims to clear the virus and reverse the abnormal cells, potentially preventing cancer. Participants receive the vaccine or a placebo, and doctors check at 6 months if the virus is gone and the cervix has healed.

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Contacts and locations

Locations

  • China Medical University Hospital

    Taichung, Taiwan, 40447, Taiwan

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung, Taiwan, 83301, Taiwan

  • Linkou Chang Gung Memorial Hospital

    Taoyuan District, Taiwan, 33305, Taiwan

    Contact

  • MacKay Memorial Hospital

    Taipei, Taiwan, 10449, Taiwan

    Contact

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

    Contact

  • National Cheng Kung University Hospital

    Tainan, Taiwan, 70403, Taiwan

  • National Taiwan University Hospital

    Taipei, Taiwan, 100225, Taiwan

    Contact

  • Taichung Veterans General Hospital

    Taichung, Taiwan, 40705, Taiwan

  • Taipei Medical University Hospital

    Taipei, Taiwan, 11031, Taiwan

  • Taipei Veterans General Hospital

    Taipei, Taiwan, 11217, Taiwan

Conditions

Explore the condition pages connected to this study.