New cream after heat treatment may help women with HIV beat HPV

NCT ID NCT07545746

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a self-applied cream (5-fluorouracil) after a heat procedure (thermal ablation) can clear HPV better than a placebo cream in 140 women with HIV in Kenya. Participants will use the cream every two weeks for 24 weeks and be followed for 48 weeks total. The goal is to reduce the risk of cervical cancer in this high-risk group.

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Conditions

The condition(s) this trial relates to.

cervical carcinoma cervical intraepithelial neoplasia cervical intraepithelial neoplasia grade 2/3 cervical squamous intraepithelial neoplasia dysplasia of cervix HIV infectious disease human papilloma virus infection Uterine Cervical Neoplasms uterine cervix carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Maseno University

    Kisumu, 614-40100, Kenya

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Nyanza Reproductive Health Society

    Kisumu, Kenya

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••