Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study compares two methods for sizing replacement heart valves in patients with a bicuspid aortic valve—a common birth defect where the aortic valve has two leaflets instead of three. Researchers want to see if using a slightly smaller valve size leads to fewer complications…

This study is testing whether a new surgical procedure can help restore vision after a sudden blockage in the eye's main artery. The procedure involves a tiny needle to deliver clot-busting medication directly into the blocked artery, combined with a standard eye surgery. Researc…

This early-stage study is testing a new cell therapy for adults with B-cell non-Hodgkin lymphoma that has come back or not responded to standard treatments. Doctors will collect natural killer (NK) immune cells from donated umbilical cord blood, genetically modify them to better …

This study is testing a new type of personalized cell therapy for people with multiple myeloma that has come back or stopped responding to other treatments. Doctors will collect and modify a patient's own immune cells (T-cells) to recognize and attack two specific targets on the …

This study is observing how well the drug ustekinumab, as part of a broader treatment plan, helps people with Crohn's disease who have developed painful intestinal narrowings (strictures). It will follow 239 patients for up to two years to see if the treatment successfully contro…

This study is testing if a newer anesthetic drug called ciprofol helps keep blood pressure more stable during surgery compared to the commonly used drug propofol. It focuses on older patients (65+) who take long-term blood pressure/heart medications, as they are at higher risk fo…

This study is testing whether a surgically implanted electrical stimulator can help people with chronic spinal cord injuries regain movement and feeling. Ten participants will have the device placed in their spine and receive personalized stimulation settings during rehabilitatio…

This study is testing a combination of three drugs given before surgery for esophageal cancer. The goal is to see if this pre-surgery treatment can shrink tumors more effectively, making surgery more successful and reducing the chance of the cancer coming back. Researchers will e…

This study aims to find out whether using a special CT scan to guide heart procedures works better than medication alone for people with chronic chest pain. Researchers will compare two approaches: one group gets procedures based on CT scan results, while the other group receives…

This study is testing whether a combination of two drugs, cadonilimab and anlotinib, can help control advanced soft tissue sarcoma that has continued to grow after standard first-line chemotherapy. It will involve about 27 adults to see if the treatment shrinks tumors and is safe…

This study is testing a personalized approach to treating early-stage HER2-positive breast cancer before surgery. All participants start with standard chemotherapy and targeted drugs. Doctors then check how well the tumor is responding. Patients with a good response continue the …

This study is testing whether adding a newer type of cholesterol-lowering drug (called a PCSK9 inhibitor) to standard treatment can better prevent heart attacks, strokes, and related deaths. It will involve about 3,600 adults who have high-risk, unstable plaque buildup in their h…

This trial is for people with breast cancer whose tumors have not shrunk after two rounds of standard chemotherapy before surgery. It tests if adding a short, targeted course of radiation (SBRT) to the continuing chemotherapy can better eliminate the cancer and allow for breast-c…

This study is testing whether guselkumab can help control Crohn's disease in patients whose previous ustekinumab treatment stopped working or caused side effects. Researchers will follow 60 adults with moderate to severe Crohn's disease for one year while they receive guselkumab …

This trial is testing whether a new AI-guided robotic system can improve surgery for a type of severe stroke called a basal ganglia hemorrhage. It will compare this high-tech, minimally invasive approach to standard care in 330 patients across multiple hospitals in China. The mai…

This study is testing a new surgical tool called VISOR for people with kidney or ureter stones. The goal is to see if it can safely break up and remove stones in one procedure, aiming to leave very few fragments behind. Participants will have surgery with the device and then get …

This study is testing whether adding an experimental drug called AK104 to standard chemotherapy and targeted therapies can help control advanced colorectal cancer that has progressed after initial treatment. The trial will enroll 40 adults with a specific type of colorectal cance…

This large study aims to find out which of two procedures is better for treating severe aortic regurgitation, a condition where a heart valve leaks. It will compare a newer, less-invasive procedure (TAVR) with traditional open-heart surgery (SAVR) in 1,250 patients aged 65 and ol…

This study is testing if adding a direct spinal fluid chemotherapy injection to standard brain cancer treatment helps adults with a particularly aggressive form of glioblastoma (GBM) that has spread to brain fluid spaces. The goal is to see if this combined approach can better co…

This study is testing whether adding a new two-drug immunotherapy (iparomlimab and tuvonralimab) to standard radiation and chemotherapy can better control advanced head and neck cancer. It will involve 27 adults with newly diagnosed, locally advanced cancer who haven't had prior …

This study is testing whether a natural protein from spirulina algae, called phycocyanin, can help treat liver scarring (fibrosis and cirrhosis). Researchers will give the supplement or a placebo to 10 adult patients for at least 4 weeks to see if it reduces liver stiffness and l…

This study is testing whether adding a tiny device called an iStent during cataract surgery helps lower eye pressure in people who also have glaucoma. Researchers will compare patients who get the stent with their cataract surgery to those who get cataract surgery alone. The goal…

This study is testing new multifocal lens implants for people with cataracts who also have other eye structure problems, like a dislocated lens or a history of eye inflammation. The goal is to see if these advanced lenses, placed with high-tech imaging guidance, provide better al…

This study aims to find out which treatment works better for early-stage frozen shoulder. It will compare a one-time procedure done under anesthesia with a supervised home exercise program. Researchers will measure pain, shoulder movement, and daily function in 300 participants t…

This study aims to see which of two existing biologic drugs, guselkumab or ustekinumab, works better for people with Crohn's disease who have developed a narrowing (stricture) in their bowel. It will follow 100 adults for a year to see if the drug successfully controls their dise…

This study is testing if a common allergy medicine, fexofenadine (like Allegra), can help people who recently had a major heart attack. It will involve 2,804 participants who will take the drug or a placebo for two years. The main goal is to see if it reduces the risk of having a…

This study aims to understand how two common treatments for swollen veins in the esophagus (varices) affect the pressure inside the liver's blood vessels over the long term. Researchers will measure this pressure using a special ultrasound technique 3-6 months after patients rece…

This study is testing whether a non-invasive brain stimulation technique can help reduce symptoms of social anxiety disorder. One hundred participants will receive either real or sham stimulation to the forehead area over one week. Researchers will track changes in anxiety levels…

This study aims to find the best maintenance therapy to help keep high-risk multiple myeloma from returning after initial treatment. It will compare two oral drug combinations in 100 patients who have already completed standard therapy. The goal is to see which approach keeps pat…

This early-stage study is testing a new way to deliver chemotherapy directly into the abdomen for people with colorectal cancer that has spread there. Doctors spray the chemo as a pressurized mist during a minimally invasive procedure, hoping it will better target the cancer. The…

This study is testing a new combination of drugs given before surgery for people with advanced head and neck cancer. The goal is to see if adding a specific immune-modulating drug (a JAK1 inhibitor) to standard immunotherapy and chemotherapy can shrink tumors more effectively. Re…

This early-stage trial is testing a new type of personalized immune cell therapy (CAR-T) for people with advanced colorectal cancer that has spread to the lining of the abdomen. The main goal is to find a safe dose and see how the body handles the treatment. Researchers will also…

This trial tests a 'rescue' strategy for patients with triple-negative breast cancer whose tumors don't shrink after initial chemotherapy. Participants receive a short, precise radiation treatment followed by immunotherapy combined with two chemotherapy drugs, aiming to shrink tu…

This study is testing whether a combination of whole-brain radiation and a chemotherapy drug injected into the spinal fluid is safe and effective for treating cancer that has spread to the lining of the brain and spinal cord. It will involve 58 adults with solid tumors who have t…

This is a first-in-human, early-stage trial testing the safety and initial effectiveness of a new type of CAR-T cell therapy called EPC-003 for adults with recurrent or treatment-resistant glioblastoma, a serious brain cancer. The therapy involves collecting and genetically modif…

This study is testing a new dietary plan designed to help Chinese patients with Crohn's disease stay in remission after having bowel surgery. It aims to see if this specific diet can improve quality of life and nutritional health better than current approaches. The diet is based …

This study is testing whether a surgically implanted electrical stimulator can help restore movement and feeling in people with recent spinal cord injuries in the lower back. Ten participants will have the device implanted and activated, then their walking ability, independence, …

This study is comparing two techniques for closing the artery after a minimally invasive heart valve replacement (TAVR). Researchers want to see if using one special closure device works as well as using two devices to prevent bleeding and other complications at the leg entry sit…

This study is testing whether adding a specialized type of radiation called spatially fractionated radiotherapy (SFRT) to a patient's standard drug treatment can better control advanced non-small cell lung cancer that has spread to a few new spots. It aims to see if this combinat…

This study is looking at whether patients with moderate-to-severe Crohn's disease or ulcerative colitis need to take a steroid pill (dexamethasone) before receiving their infliximab infusion to prevent allergic reactions. Researchers want to see if skipping this pre-medication fo…

This study is testing a modified chemotherapy regimen given before a patient's own stem cells are transplanted back into them. It is for people with non-Hodgkin lymphoma who are at high risk of the cancer spreading to their brain or spinal cord. The goal is to see if this approac…

This study is testing whether taking spirulina tablets can help protect the liver and help it heal faster after surgery to remove part of it for bile duct cancer. Researchers will give 30 participants either spirulina or a placebo pill for 3 weeks before and 3 weeks after their o…

This study is testing whether a surgically implanted spinal cord stimulator, combined with intensive physical therapy, can help people with certain spinal cord injuries walk better. Researchers will implant the device in 12 participants and measure their walking ability, independ…

This study is testing if adding a common amino acid called leucine to the standard pre-surgery treatment (chemotherapy and radiation) can help shrink tumors more effectively in people with locally advanced rectal cancer. The goal is to see if this combination leads to better outc…

This early-stage study is testing a new treatment for B-cell lymphoma that has come back or not responded to other therapies. The treatment uses a modified virus designed to both attack cancer cells directly and instruct the patient's own immune system to target them. Researchers…

This study is testing whether a new version of an existing chemotherapy drug, packaged in tiny fat bubbles called liposomes, works better and is safer when combined with other cancer drugs for advanced colorectal cancer. It's for patients whose first treatment has stopped working…

This early-stage trial is testing the safety of a new type of personalized mRNA vaccine designed to treat aggressive brain tumors that have returned or worsened after standard treatment. The study will enroll 10 patients to see if the vaccine is safe and if it can trigger the imm…

This study is testing if adding radiation therapy after surgery helps prevent early-stage tongue cancer from returning in patients who have certain risk factors. Researchers will compare two groups: one that receives radiation after surgery and one that is simply monitored. They …

This study aims to closely watch 120 people with early Alzheimer's disease who are taking the drug lecanemab. Researchers will track changes in their brain scans, memory, thinking, and daily life over 18 months to see how well the drug works and monitor for any side effects. The …

This early-stage study is testing a new cell therapy for people with severe autoimmune diseases that haven't improved with standard treatments. Doctors will give patients specially engineered immune cells (CAR-NK cells) to try to reset their overactive immune systems. The main go…

This study is testing an oral drug called vebreltinib for people with advanced clear cell sarcoma, a rare and aggressive cancer. It aims to see if the drug can shrink tumors and control the disease. The trial will enroll about 30 patients and compare their outcomes to a group rec…

This study is testing if a newer, 'leave-nothing-behind' treatment using a drug-coated balloon is as safe and effective as the standard drug-eluting stent for people having a major heart attack (STEMI). It will enroll about 1,244 patients across China who are having emergency hea…

This large trial is testing whether a new, less invasive brain surgery guided by artificial intelligence and a robot can improve recovery for people who have suffered a severe bleeding stroke. It will compare this high-tech approach to standard surgical or medical care across fou…

This study is testing whether adding a new immunotherapy drug called pucotenlimab to the standard pre-surgery treatment (chemotherapy and radiation) works better for people with locally advanced rectal cancer. The goal is to see if this combination helps more patients achieve a c…

This early-stage study is testing a new type of personalized immune cell therapy called CAR-T for people with advanced lung or breast cancer that has stopped responding to standard treatments. The therapy involves collecting a patient's own immune cells, modifying them in a lab t…

This study is testing a new type of CAR-T cell therapy, called TRBC1/2 CAR-T, for adults whose peripheral T-cell lymphoma has come back or hasn't responded to at least one prior treatment. The main goals are to find a safe dose and see if the therapy can shrink or eliminate the c…

This study is testing a new way to deliver medicine directly into the cornea (the clear front part of the eye) to treat abnormal blood vessel growth caused by herpes eye infections. Researchers want to see if this targeted injection is safe and effective at reducing these blood v…

This study is testing a new type of personalized cell therapy called LILRA6 CAR-T for adults whose acute myeloid leukemia has come back or hasn't responded to standard treatments. The main goals are to find a safe dose and see if the therapy can help control the cancer. This is a…

This study aims to develop an artificial intelligence (AI) tool that can predict whether breast cancer will spread to other parts of the body. Researchers will analyze existing tissue samples from 400 patients who had breast cancer surgery between 2015 and 2025. The AI will exami…

This study is testing if a quick, non-invasive scan of the back of the eye (the retina) can help doctors diagnose Parkinson's disease in its early stages. Researchers will compare the eye scan's accuracy to a more complex and expensive brain scan currently used for diagnosis. The…

This study is testing whether artificial intelligence (AI) can help doctors better diagnose and classify hypertrophic cardiomyopathy, a serious heart muscle disease. Researchers will use AI to analyze standard heart tracing tests (ECGs) from 15,000 participants to see if it can a…

This study is testing a new method to create a detailed 3D computer model of the entire eye. The goal is to help doctors better understand complex eye conditions, like difficult cataracts, before surgery. Researchers will combine several imaging scans to build the model, hoping i…

This study is testing a new artificial intelligence (AI) tool designed to analyze PET/CT scans and patient information. The goal is to help doctors quickly and accurately identify the specific type and genetic features of a patient's lung cancer. Researchers will use data from 5,…

This study is developing an artificial intelligence (AI) system to help doctors analyze MRI scans and identify different types of malignant brain tumors. It will use data from 3000 adults with confirmed brain tumors to train the AI. The goal is to create a tool that makes non-inv…

This study aims to find early warning signs in the blood that can predict which cancer patients will develop severe, painful dry mouth after radiotherapy. Researchers will collect blood samples from 126 head and neck cancer patients before and after their treatment. The goal is t…

This study is testing if a steroid injection in the buttock muscle works as well as a more precise, ultrasound-guided injection directly into the shoulder joint for treating frozen shoulder. Researchers will enroll 528 adults with painful, stiff shoulders to compare how much pain…

This study tests whether a combination of common non-opioid pain medications (celecoxib and acetaminophen) works as well as opioid-based pain relief for patients recovering from minimally invasive ankle surgery. Researchers will compare pain levels and side effects in 110 adults …

This study aims to find the best single dose of a pain medication called tegileridine for adults recovering from bone or joint surgery. Researchers will test different doses in 180 patients to see which one effectively controls pain for 90% of people shortly after waking up from …

This study is testing a traditional Chinese medicine patch applied to specific points on the skin to relieve constipation and fatigue in people with colorectal cancer who are undergoing chemotherapy after surgery. Researchers will compare the patch treatment to standard care in 1…

This study is testing if a fecal microbiota transplant (FMT), which transfers healthy gut bacteria from a donor, can help reduce nausea, vomiting, and diarrhea caused by chemotherapy or targeted therapy. It will involve 90 adults with advanced gastrointestinal cancers who have al…

This study is testing if numbing the nerves around the ankle before a common 'keyhole' surgery helps control pain in the first day after the operation. Researchers will compare this approach to a placebo in 70 patients to see if it reduces the need for strong painkillers. They wi…

This study is testing a new, faster schedule of non-invasive brain stimulation to see if it can better relieve chronic nerve pain. Researchers are comparing this accelerated method against the standard stimulation treatment in 120 adults who have had nerve pain for at least three…

This study is investigating whether popular weight-loss medications like semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) can slow down or reverse accelerated aging at the genetic level in adults with obesity. Researchers will enroll 66 adults with obesity and mea…

This study is developing a computer tool to predict if and where breast cancer might spread in the body. Researchers will use artificial intelligence to analyze tissue samples from 2,000 women diagnosed with breast cancer. The goal is to create a more precise prediction system to…

This study aims to understand how bacteria in the lungs of people with bronchiectasis change over time. Researchers will collect sputum samples from 1850 patients every month for three years to analyze these bacteria. The goal is to learn if changes in these bacteria can predict …

This study is testing a new method to help doctors control how deeply a patient is asleep during surgery. Researchers will measure the levels of anesthetic drugs in a patient's exhaled breath in real-time and see how well this matches the patient's brain activity. The goal is to …

This study aims to understand how the brain processes imagined Mandarin Chinese speech by recording electrical signals directly from the brain's surface. It involves patients who are already having brain surgery for conditions like epilepsy or tumors, or those with severe speech …

This study aims to understand how moderate heart valve disease gets worse over time. It will follow 10,000 adults in China, using regular heart scans and blood tests to track their condition. The goal is to find early warning signs and see how different treatments affect the dise…

This study aims to understand if problems with the heart's smallest blood vessels affect the long-term health of people with dilated cardiomyopathy (DCM), a condition where the heart muscle is weakened and enlarged. Researchers will observe 330 patients with DCM to see if this sm…

This study aims to find objective biological markers in the brain to help diagnose and track treatment for severe mental disorders like depression, schizophrenia, and bipolar disorder. Researchers will use a powerful 7T MRI scanner and vision tests to compare brain chemistry and …

This study aims to understand how radiation used during cancer surgery affects a patient's own red blood cells. Researchers will examine blood from 20 cancer surgery patients to see how different radiation doses change the cells' shape, flexibility, and ability to carry oxygen. T…

This study aims to understand the long-term health of people who receive liver transplants and the living donors who give part of their liver. Researchers will follow nearly 10,000 participants for years to identify what factors lead to complications and better health. The goal i…