Second Affiliated Hospital, School Of Medicine, Zhejiang University

This study tests a technique called acute normovolemic hemodilution (ANH) in 150 adults undergoing bone tumor surgery. Before surgery, some blood is removed and replaced with fluid, so that if bleeding occurs, the patient loses less red blood cells. The goal is to see if this red…

This phase 2 trial tests whether adding tafolecimab (a cholesterol-lowering drug) to standard chemotherapy and the immunotherapy sintilimab helps people with extensive-stage small cell lung cancer live longer without their cancer growing. About 40 adults who have not had prior tr…

This phase 2 trial tests a combination of two drugs—lucankizumab and goleirex—as a first treatment for people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. The study will enroll 43 participants to see if the combo shrinks tumors and how safe it …

This phase II trial tests whether an intensified treatment plan can delay tumor growth in adults with high-risk glioblastoma that was only partially removed or came back quickly. Participants receive higher radiation doses to the remaining tumor, plus chemotherapy and two immunot…

This pilot study tests whether focused ultrasound, combined with tiny gas bubbles (microbubbles), can help chemotherapy drugs penetrate deeper into HER2-positive breast tumors. Twenty women will receive the ultrasound treatment alongside standard neoadjuvant therapy before surger…

This study looks at whether keyhole surgery (laparoscopic) or traditional open surgery leads to better long-term results for colon cancer patients who have extra belly fat. About 664 adults aged 18 to 75 with colon cancer and a high Body Roundness Index will take part. The main g…

This study tests whether giving a combination of iron, erythropoietin, and vitamin C before major heart surgery can lower the need for blood transfusions in adults with iron-deficiency anemia. About 400 participants will receive either the combined regimen or standard care. The g…

This study looks at two different surgeries for advanced ovarian cancer that has spread to the bowel. One method removes only the tumor from the bowel, while the other removes a piece of the bowel along with the tumor. The goal is to see which approach helps patients live longer …

This phase II study tests a personalized approach for women with a common type of early breast cancer (HR+/HER2-). All 45 participants start with a combination of culmerciclib and hormone therapy. If the tumor responds well, they continue; if not, they switch to a different treat…

This study tests a new drug called fovinaciclib combined with hormone therapy and targeted antibodies in people with early-stage HR-positive/HER2-positive breast cancer. After 6 weeks, doctors check if the tumor is shrinking. If it is, patients continue the same treatment; if not…

This study tests a device that sends electrical pulses to the spinal cord, combined with daily rehab, to help people with chronic spinal cord injury regain walking ability. Twelve participants will receive the implant and be followed for over a year. The goal is to see if the app…

This study tests a new early in-hospital temperature management protocol for heat stroke patients. The protocol includes early identification, rapid cooling methods, and precise temperature monitoring. Researchers aim to see if this approach improves cooling rates and reduces dea…

This study looks at whether gut bacteria are linked to central serous chorioretinopathy (CSC), an eye condition that causes fluid buildup and vision problems. Researchers will compare gut bacteria in 400 people with and without CSC. They will also give some participants a Bifidob…

This study tests whether adding an immunotherapy drug (anti-PD-1) and a diabetes drug (sitagliptin) to standard chemotherapy can shrink tumors before surgery in people with locally advanced colorectal cancer that has a specific genetic profile (pMMR). About 138 adults aged 18–75 …

This phase II trial tests whether taking leucogen alongside standard ribociclib therapy can prevent severe neutropenia (dangerously low white blood cell counts) in women with early-stage hormone-positive breast cancer. About 94 participants will receive the combination and be mon…

This early-phase trial tests a new cell therapy for people with T-cell lymphoma or acute myeloid leukemia that has come back or not responded to standard treatments. The therapy uses immune cells (NK cells) from donated cord blood that are engineered to recognize and attack cance…

This study tests a personalized approach to deep brain stimulation (DBS) for people with depression that hasn't improved with other treatments. Researchers use brain scans and recordings to find the best spot and settings for each person's implant. The goal is to see if this tail…

This study tests whether an implanted device that sends electrical pulses to the spinal cord can improve movement and feeling in people with chronic spinal cord injuries. Ten participants with injuries above the T10 level will receive the implant and undergo regular assessments o…

This study tests a combination of a standard liver cancer procedure (TACE) with three immunotherapy drugs (sintilimab, bevacizumab, and ipilimumab) in 36 adults with advanced liver cancer that cannot be removed by surgery. The goal is to see if this mix is safe and works better t…

This phase 2 trial tests whether adding envafolimab (an immunotherapy) to standard chemotherapy (doxorubicin and ifosfamide) can improve outcomes for people with advanced soft tissue sarcoma who haven't had prior treatment. About 25 adults will receive the combination every 3 wee…

This early-phase trial tests an injection of special brain cells (GABAergic interneuron progenitors) in 6 adults with drug-resistant mesial temporal lobe epilepsy. The goal is to see if the treatment is safe and can reduce seizure frequency. Participants will receive the cell the…

This study compares the effectiveness and safety of different doses and schedules of guselkumab in 400 Chinese adults with moderate to severe plaque psoriasis. Participants will receive either a high dose, an extended-interval dose, or the standard dose. The goal is to find the b…

This study looks at whether giving anemic patients a combination of iron, erythropoietin, and vitamin C for three days before heart surgery can improve their quality of life, sleep, and fatigue over the long term. Researchers will compare these patients to those receiving standar…

This phase 2 trial tests whether two drugs, cadonilimab and anlotinib, can help people with advanced or metastatic soft tissue sarcoma whose first treatment stopped working. About 27 adults will receive the combination to see if it slows tumor growth. The study is currently recru…

This phase 2 trial tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent glioblastoma from spreading to the brain and spinal cord lining. The study enrolls 38 newly diagnosed patients whose tumors touch brain fluid spaces or whose surgery …

This phase II trial is testing whether a special type of radiation therapy (SFRT) given before surgery can improve outcomes for people with large soft tissue sarcomas (at least 5 cm) in the limbs or trunk. About 22 adults will receive 5 doses of SFRT, then have surgery about a we…

This study tests whether combining guselkumab with JAK inhibitors (upadacitinib or tofacitinib) can help people with inflammatory bowel disease that hasn't improved with other treatments. About 80 participants will receive the drug combination and be monitored for 12 and 52 weeks…

This study looks at whether a drug called guselkumab can help people with moderate to severe Crohn's disease who did not improve or could not tolerate another drug called ustekinumab. About 60 adults will receive guselkumab and be followed for 52 weeks. The main goal is to see ho…

This early-stage trial is testing a new treatment for people with relapsed or refractory peripheral T-cell lymphoma, a rare and aggressive blood cancer. The therapy uses immune cells (NK cells) from donated umbilical cord blood that are genetically modified to recognize and attac…

This study tests a modified stem cell transplant regimen for lymphoma patients at high risk of the cancer spreading to the brain. About 45 adults who have already responded to initial treatment will receive high-dose chemotherapy with thiotepa, etoposide, cytarabine, and melphala…

This study tests whether a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE device is as safe and effective as traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults…

This phase 2 trial tests a new combination of drugs—imaxitinib, chemotherapy, and immunotherapy—given before surgery for advanced head and neck cancer. The goal is to see if this approach can shrink tumors more effectively, making surgery easier or possible for patients whose can…

This study tests a new approach for people with triple-negative breast cancer whose tumors don't shrink after standard chemotherapy. Participants receive targeted radiation to the tumor followed by immunotherapy (toripalimab) plus more chemo. The goal is to see if this combinatio…

This study looks at two drugs, guselkumab and ustekinumab, in 100 adults with moderate-to-severe Crohn's disease that has caused narrowing (strictures) in the bowel. The goal is to see which drug better controls symptoms and improves imaging results over 52 weeks. Participants co…

This phase 2 trial tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemoradiotherapy can improve outcomes for people with locally advanced head and neck cancer. The study will enroll 27 participants and track how many remain cancer-free aft…

This study is testing whether the drug ustekinumab (Stelara) can help people with moderate-to-severe Crohn's disease who also have bowel strictures (narrowing of the intestine). About 239 participants will receive ustekinumab and be followed for a year. The goal is to see if the …

This study looks at whether giving radiation therapy after surgery can delay the return of early-stage tongue cancer in patients who have certain risk factors. About 190 adults aged 18 to 70 will be randomly assigned to either receive radiation or just be monitored. The goal is t…

This early-phase study tests a new approach for patients with B-cell lymphoma that has not responded to standard treatments. A specially designed virus is injected to deliver instructions that turn some of the patient's own immune cells into cancer-killing cells directly inside t…

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard treatment can prevent heart attacks, strokes, and death in people with high-risk coronary plaques seen on CT scans. About 3,600 adults with at least one severely narrowed or high-ri…

This study looks at two ways to treat people with chronic coronary artery disease (narrowed heart arteries). One group gets a special CT scan to find blocked arteries and then receives procedures like stents or bypass surgery. The other group gets only medications and lifestyle a…

This study is testing whether fexofenadine, a common allergy medication, can reduce the risk of serious heart and brain events in people who have recently had a heart attack. About 2,800 participants will receive either fexofenadine or a placebo for 24 months. The goal is to see …

This study tests whether a diet that removes refined and intolerant foods can help people with Crohn's disease stay in remission after bowel surgery. Researchers will track quality of life and nutrition in 35 participants. The goal is to create a practical dietary plan for Chines…

This study tests if a drug-coated balloon works as well as a drug-coated stent for people having a severe heart attack (STEMI). About 1,200 participants will receive either the balloon or the stent during emergency artery-opening procedures. The goal is to see if the balloon, whi…

This study is testing whether adding leucine, a common amino acid found in food, to standard chemoradiotherapy can help shrink tumors more effectively in people with locally advanced rectal cancer. The researchers believe leucine may interfere with cancer cells' ability to repair…

This study tests a small device called iStent that is placed in the eye during cataract surgery to help lower pressure in people with open-angle glaucoma. Sixty adults with both glaucoma and cataracts will be enrolled. The goal is to see if the iStent is safe and effective at red…

This phase 2 trial is for people with HER2-positive early breast cancer. After initial standard therapy, those who don't respond well will switch to a stronger combination of newer drugs, including trastuzumab-rezetecan and pyrotinib. The goal is to see if this personalized appro…

This study is testing a new type of CAR-T cell therapy that targets two proteins (CD19 and BCMA) on myeloma cells. It is for people whose multiple myeloma has come back or stopped responding to other treatments. The goal is to see if this dual-target approach is safe and can shri…

This early-stage trial tests a new way to deliver chemotherapy for colorectal cancer that has spread to the lining of the abdomen. Doctors use a spray (PIPAC) to send the drugs mitomycin or raltitrexed directly into the belly during a keyhole surgery. The main goal is to find a s…

This study tests whether an AI-guided robotic system can improve outcomes for people with a moderate brain bleed (basal ganglia hemorrhage). About 330 adults will be randomly assigned to receive either the AI-assisted minimally invasive surgery or standard care. The goal is to se…

This study tests whether injecting anti-VEGF medication directly into the cornea can safely reduce abnormal blood vessel growth caused by herpes simplex keratitis. One hundred adults will receive either the injection plus antiviral eye drops or standard antiviral drops alone. Res…

This large trial is testing whether AI-guided robotic surgery can improve outcomes for people with a hemorrhagic stroke (bleeding in the brain). The study will compare this new, less invasive technique to standard surgery or medical management. Researchers hope the robotic approa…

This study tests special lens implants that correct both cataracts and presbyopia (age-related blurry near vision) in patients with additional eye structure issues like lens dislocation or inflammation. About 320 adults will receive these lenses during cataract surgery, with doct…

This phase 4 study tests whether adding a low dose of lenalidomide to ixazomib works better than ixazomib alone as long-term maintenance therapy for people with high-risk multiple myeloma. About 100 participants who have already completed initial treatment will be followed to see…

This study tests whether ciprofol, a newer anesthetic, causes fewer dangerous blood pressure drops during surgery compared to the standard drug propofol. It involves 140 elderly patients (65+) who take blood pressure medications and are having abdominal surgery. The goal is to se…

This study is for people with breast cancer whose tumors did not shrink after two rounds of standard chemotherapy. It tests whether adding a short course of targeted radiation (SBRT) to continued chemotherapy can help eliminate more cancer before surgery. About 96 participants wi…

This study tests a new treatment using specially engineered immune cells (CAR-NK) from cord blood for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis that haven't responded to standard therapies. The goal is to see if it's safe and can control the d…

This early-stage trial tests a universal mRNA vaccine designed to target common mutations in high-grade glioma, a type of aggressive brain cancer. Ten patients with recurrent or progressive disease will receive the vaccine to see if it is safe and can stimulate an immune response…

This study tests a new form of chemotherapy (liposomal irinotecan) combined with standard drugs for people with advanced colorectal cancer that has not responded to first treatment. About 100 adults aged 18-75 will receive this combination to see if it shrinks tumors and delays c…

This study will give 66 adults with obesity either semaglutide (Ozempic/Wegovy), tirzepatide (Mounjaro/Zepbound), or metformin for 24 weeks. Researchers will use a DNA test called iWatchAge to see if these drugs can reverse or slow the genetic signs of aging. The goal is to find …

This study tests whether phycocyanin, a natural protein from spirulina, can improve liver health in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks. Researchers will measure changes in liver stiffness …

This early-stage trial tests a new type of immune cell therapy called LILRA6 CAR-T for people with acute myeloid leukemia that has come back or not responded to standard treatment. The therapy uses a patient's own T cells, modified in a lab to target leukemia cells. The study wil…

This study tests whether combining the immunotherapy adbelimumab with chemotherapy and the targeted drug apatinib can help shrink esophageal tumors before surgery. About 35 adults with resectable esophageal squamous cell carcinoma will receive four cycles of the drug combo, then …

This study tests whether taking spirulina tablets before and after liver surgery can protect the liver and help it recover faster. Thirty adults with bile duct cancer will take either spirulina or a placebo for three weeks before and three weeks after surgery. Researchers will me…

This early-stage study is testing a new treatment called CEA-targeted CAR-T cells in people with advanced non-small cell lung cancer or breast cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells, modified to recognize and attack ca…

This phase 2 trial is testing whether adding an immunotherapy drug (AK104) to standard chemotherapy and a targeted therapy (cetuximab or bevacizumab) can shrink tumors in people with a specific type of advanced colorectal cancer (MSS type) that has already been treated once. The …

This early-stage trial tests a personalized cell therapy (CAR-T cells) designed to attack a protein called CEA found on colorectal cancer cells. The therapy is given directly into the abdomen after surgery to remove visible tumors. The study will enroll 12 adults whose cancer has…

This early-stage trial tests a new therapy made from cord blood immune cells (CAR NK cells) designed to target and kill B-cell lymphoma cells. It is for patients whose cancer has not responded to or has returned after standard treatments. The study will check safety and how well …

This early-phase trial is testing a new type of immunotherapy called CAR-T cells in 14 people with glioblastoma that has come back or not responded to treatment. The CAR-T cells are designed to target two proteins found on glioblastoma cells and are given directly into the fluid …

This study tests whether using one stitch device (Perclose) is as safe and effective as using two to close the leg artery after a minimally invasive heart valve replacement (TAVR) in people with severe aortic stenosis. About 876 participants will be randomly assigned to one of th…

This study tests whether a device that sends electrical pulses to the spinal cord can help people with chronic spinal cord injuries regain movement and feeling. Ten participants with injuries between the T11 and L3 vertebrae will receive the implant and undergo rehabilitation. Re…

This study tests whether using a slightly smaller artificial heart valve (downsizing) works better than the standard method for people with a bicuspid aortic valve—a heart valve with only two flaps instead of three. About 206 adults with severe narrowing of this valve will be ran…

This phase 2 trial tests the drug vebreltinib in 30 people with advanced clear cell sarcoma, a rare cancer of the soft tissues. Participants take the drug as a capsule twice daily until the cancer worsens or side effects become too severe. The main goal is to see if the drug can …

This trial tests a new device called VISOR for removing kidney stones. It combines stone breaking, suction, and pressure control in one tool. About 20 adults with 1-3 cm stones will undergo surgery with VISOR. The goal is to see if it clears stones safely and effectively, with a …

This study tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can help people with glioblastoma that has invaded the brain's ventricles or lining. Participants will first have surgery to remove as much tumor as possible, then receive radiation, ora…

This study tests whether adding a special type of radiation (SFRT) to standard cancer treatment can help control non-small cell lung cancer that has started to grow again after initial therapy. About 25 adults whose cancer has progressed in a limited number of spots will receive …

This study tests whether adding the immunotherapy drug pucotenlimab to standard chemoradiation can improve outcomes for people with locally advanced rectal cancer. About 68 participants will receive the combination, and doctors will check if the tumor disappears completely. If it…

This study follows 120 people with early Alzheimer's or mild cognitive impairment who are taking lecanemab, an FDA-approved drug that targets amyloid plaques in the brain. Researchers will track changes in memory, daily function, and brain scans over 18 months to see if the drug …

This trial tests a new procedure for people who suddenly lose vision due to a blocked artery in the eye. Surgeons will use a tiny microneedle to deliver clot-busting medicine directly into the artery during eye surgery. The study will compare this approach to standard care in 24 …

This study is testing whether proteins in the blood can help detect liver cancer at an early stage. Researchers will compare blood samples from 600 people—some with liver cancer and some healthy—to find protein patterns that signal the disease. The goal is to create a simple, non…

This study tests an artificial intelligence (AI) model that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to see how well the AI catches moderate-to-severe cases without needing extra tests or contrast dye.…

This study compares a new type of CT scanner (photon-counting CT) with standard CT to see if it can better detect very small blood clots in the lungs, called subsegmental pulmonary embolism. About 696 adults with suspected acute pulmonary embolism will be scanned with both method…

This study is testing whether an artificial intelligence (AI) system can accurately identify different types of lung cancer by analyzing PET/CT scans and patient information like age, smoking history, and tumor markers. Researchers aim to improve how doctors distinguish between s…

This study is testing whether creating a full 3D model of the eye can help doctors better plan surgeries for people with complex cataracts and eye structure problems. Researchers will combine scans from multiple imaging tools to build the model. The goal is to improve surgical ac…

This study uses artificial intelligence to analyze standard electrocardiograms (ECGs) to accurately diagnose hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. The AI will also help tell HCM apart from other diseases that look similar, like high blood…

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the eye scan results with standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders, …

This study is building a large database of MRI scans from 3000 adults with malignant brain tumors (gliomas, metastases, lymphomas). Researchers will train an artificial intelligence system to automatically identify and classify these tumors. The goal is to improve non-invasive di…

This small study tests whether electrical stimulation of the spinal cord can improve arm and leg movement in people who had a stroke at least 6 months ago. Only 6 participants with limited recovery will receive the treatment. The goal is to see if it is safe and helps with daily …

This study tests whether a corticosteroid injection into the gluteal muscle works as well as an ultrasound-guided injection into the shoulder joint for treating frozen shoulder. About 528 adults aged 18 to 65 with frozen shoulder will receive one injection and be followed for 12 …

This study tests whether a combination of two drugs, fosrolapitant and palonosetron, plus a steroid, can prevent nausea and vomiting caused by chemotherapy and immunotherapy in people with esophageal or lung cancer. About 120 participants will receive the drug before each chemo c…

This study tests whether a cooling blanket helps people with heat stroke cool down faster than standard methods like ice packs and cool fluids. About 126 adults with heat stroke will be randomly assigned to receive either the cooling blanket or usual care. The goal is to see if t…

This study tests whether a type of magnetic brain stimulation called iTBS can help people with PTSD. Researchers will give 140 adults either real or fake (sham) stimulation to see if it reduces symptoms like flashbacks and anxiety. The goal is to find a new, non-drug treatment op…

This study tests whether pressing tiny seeds on specific ear points, combined with a steroid drug (dexamethasone), can prevent or reduce nausea and vomiting caused by chemotherapy in breast cancer patients. About 25 women will receive this treatment before chemo and track their s…

This study tests whether combining ear acupressure (using small seeds on specific ear points) with the steroid dexamethasone can better prevent or reduce nausea and vomiting caused by chemotherapy in pancreatic cancer patients. About 25 participants will receive the treatment bef…

This study tests whether pressing on specific ear points (with tiny seeds) plus a steroid drug can prevent nausea and vomiting caused by a breast cancer treatment. About 25 adults with breast cancer will try this approach and track their symptoms for five days. The goal is to fin…

This study is testing whether a non-invasive brain stimulation method called intermittent theta-burst stimulation (iTBS) can reduce symptoms of social anxiety disorder. One hundred adults with social anxiety will receive either real iTBS (to the left or right prefrontal cortex) o…

This study tests whether numbing specific nerves in the leg before ankle surgery can lower pain and help people recover faster. About 70 adults having ankle arthroscopy will receive either a nerve block or a placebo injection, along with standard anesthesia. Researchers will meas…

This study looks at whether people with moderate-to-severe inflammatory bowel disease (IBD) need to take a steroid (dexamethasone) before each infliximab infusion to prevent allergic reactions. Researchers will compare those who get the steroid routinely with those who only get i…

This study tests a new, faster type of brain stimulation (called AiTBS) to see if it relieves nerve pain better than the standard method. 120 adults with long-term nerve pain will receive either AiTBS or standard stimulation over 10 days. Researchers will measure pain levels and …

This study tests a single injection of tegileridine fumarate, a new painkiller, for adults recovering from orthopedic surgeries like spinal fusion or knee replacement. Researchers aim to find the dose that works for 90% of patients without causing too many side effects. 180 parti…

This study tests whether fecal microbiota transplantation (FMT) – taking donor gut bacteria in capsules – can prevent or reduce gastrointestinal symptoms like nausea, vomiting, and diarrhea caused by chemotherapy or targeted therapy. It involves 90 adults with advanced (Stage IV)…

This study compares two treatments for early frozen shoulder (adhesive capsulitis): manipulation under anesthesia and a supervised home rehabilitation program. Researchers will enroll 300 adults aged 40 to 80 whose shoulder symptoms started within the last 3 months. The goal is t…

This study tests whether acupoint application (sticking herbal pastes on specific body points) can relieve constipation and qi deficiency in people with colorectal cancer who have had chemotherapy. About 106 adults will be randomly assigned to receive either the acupoint treatmen…

This study investigates whether a small RNA molecule called tRF-31 is linked to the severity of age-related cataracts. Researchers will collect lens tissue from 200 adults undergoing routine cataract surgery and measure tRF-31 levels. The goal is to see if higher or lower levels …

This study is creating a large database of information from 10,000 adults undergoing heart surgery. Researchers will collect detailed data before, during, and after surgery to identify factors that affect recovery and complications. The goal is to improve risk prediction, persona…

This study looks at whether a special CT scan (CT-FFR) can help doctors predict heart attacks and other serious events in people with chronic coronary syndrome. About 3,000 participants in China will be followed for up to 5 years. The goal is to see if abnormal CT-FFR results are…

This study aims to build an AI model that uses medical images and tissue samples to predict which liver cancer patients will benefit from additional treatments after surgery. Researchers will analyze data from 11,000 patients to see if the AI's recommendations match real-world ou…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study uses powerful 7T MRI scanners and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare brain chemistry and vision in 320 patients and healthy volunteers. The …

This study is investigating why some patients with normal pressure hydrocephalus (a condition that causes walking problems, memory loss, and incontinence) improve after a shunt surgery that drains extra fluid from the brain. Researchers will analyze proteins in the spinal fluid o…

This study looks at two types of minimally invasive surgery for central lung cancer: robotic-assisted (RATS) and video-assisted (VATS). Researchers want to see which one helps patients live longer without cancer coming back. About 450 adults with non-small cell lung cancer will t…

This study follows 500 people who are already scheduled for routine shoulder or knee surgery for sports injuries. Researchers will track their recovery over two years using questionnaires about pain and function. The goal is to find out which factors—like injury type or surgical …

This study looks at how the brains of 25 stroke patients with weak hand muscles activate during mirror movement therapy. Researchers use a special brain scanner to measure activity. The goal is to understand brain changes, not to test a treatment.

This study is creating a digital platform to assess and reduce disability risk in adults aged 65 and older. Researchers will screen for risk factors, build an early warning system, and test the platform in urban and rural communities with 238 participants. The goal is to help old…

This observational study looks at gum tissue from people with aggressive or chronic periodontitis and healthy gums. Researchers use advanced genetic tools to map cell types and signals that make aggressive disease different. Only small tissue and blood samples are taken during pl…

This study investigates whether brain surface recordings can decode Mandarin Chinese speech, including tones, from imagined speech. About 50 participants with brain tumors or epilepsy will have temporary electrodes placed during surgery, and 10 people with severe speech loss will…

This study aims to build an AI system that uses tumor samples and genetic data to predict if and where breast cancer will spread (to bones, lungs, liver, or brain). Researchers will analyze data from 2000 women diagnosed with breast cancer. The goal is to help doctors personalize…

This study uses artificial intelligence to analyze standard tissue samples from breast cancer patients. The goal is to predict which patients are at higher risk of the cancer spreading to other parts of the body. Researchers will train the AI on slides from 400 women who had surg…

This study looks at how X-ray irradiation used during cancer surgery affects red blood cells. Researchers will take blood from 20 patients having tumor surgery and test it with different X-ray doses. They will check for changes in cell shape, flexibility, and oxygen-carrying abil…

This study follows thousands of liver transplant recipients and living donors over many years. Researchers collect health data to find out what leads to complications and how to improve care. The goal is to create better follow-up plans and improve quality of life for both groups…

This study looks at how problems in the heart's tiny blood vessels (coronary microvascular dysfunction) affect long-term outcomes in people with dilated cardiomyopathy, a condition where the heart muscle is enlarged and weak. Researchers will follow 330 participants who have alre…

This study explores whether analyzing a patient's exhaled breath can accurately measure the depth of anesthesia during surgery. Researchers will compare breath concentrations of two common anesthetics with standard brain wave monitoring (BIS) in 500 adults. The goal is to develop…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This study looks at how two common endoscopic treatments—band ligation and sclerotherapy—change blood pressure in the liver's portal vein over 3 to 6 months. Researchers will use a special ultrasound-guided technique to measure these pressure changes in 70 adults with cirrhosis a…

This study follows 1,850 bronchiectasis patients over three years, collecting sputum samples monthly to analyze how lung bacteria change over time. Researchers will sequence the DNA of bacteria like Pseudomonas aeruginosa to see how they evolve and become resistant to antibiotics…

This study is looking for early biological markers in the blood that could predict dry mouth caused by radiation therapy in head and neck cancer patients. Researchers will collect blood samples from 126 patients before and after treatment and use advanced techniques to find these…