Brain fluid analysis may predict shunt success in elderly

NCT ID NCT04998175

Recruiting now Knowledge-focused Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is investigating why some patients with normal pressure hydrocephalus (a condition that causes walking problems, memory loss, and incontinence) improve after a shunt surgery that drains extra fluid from the brain. Researchers will analyze proteins in the spinal fluid of 40 older adults before and after surgery, and compare them to healthy volunteers. The goal is to find biological markers that predict who will benefit from the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ventriculoperitoneal shunt
What this could lead to: If successful, this research could help doctors predict which patients will benefit most from shunt surgery, improving treatment decisions.
What could go wrong: This is a small, early-stage observational study, not a treatment trial. It may not identify clear predictors or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

normal pressure hydrocephalus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS

Contacts and locations

Locations

The second affliated hospital of zhejiang university
RECRUITING

Hangzhou, Zhejiang, 310009, China

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