Brain shunt surgery put to the test in Placebo-Controlled trial
NCT ID NCT05081128
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a brain shunt—a device that drains extra fluid—can improve walking and thinking in older adults with idiopathic normal pressure hydrocephalus (iNPH). One hundred participants will either receive an active shunt or a placebo procedure. The main goal is to see if the active shunt improves gait speed after three months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
programmable CSF shunt valve (brain shunt surgery)
What this could lead to
If successful, this trial could confirm that shunt surgery effectively improves walking and thinking in people with normal pressure hydrocephalus.
What could go wrong
This is a relatively small, early-stage trial with 100 participants, and results may not apply to all patients. Shunt surgery carries risks like infection or over-drainage of fluid.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Emory University
Atlanta, Georgia, 30322, United States
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Indiana University
Indianapolis, Indiana, 46202, United States
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Mount Sinai Health System
New York, New York, 10029, United States
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New York University Langone Health
New York, New York, 10016, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Pacific Neuroscience Institute
Santa Monica, California, 90404, United States
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The University of Texas Southwestern Medical Center
Dallas, Texas, 75390-8855, United States
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Umeå University
Umeå, 901 87, Sweden
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University of British Columbia
Vancouver, Canada
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University of Calgary
Calgary, Alberta, AB T2N 1N4, Canada
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University of California, Davis
Davis, California, 95616, United States
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University of South Florida
Tampa, Florida, 33612, United States
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University of Southern California
Los Angeles, California, 90089, United States
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University of Washington
Seattle, Washington, 98195, United States
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Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157-1029, United States