Saving the ligament: a trial tests whether repairing a torn ACL beats replacing it
NCT ID NCT05584020
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial compares two surgical approaches for acute anterior cruciate ligament (ACL) tears: repairing the native ligament with strong sutures versus the standard reconstruction that replaces it with a tendon graft. The study enrolls patients with certain tear types (Sherman grades I and II) who are treated within three weeks of injury. Researchers will measure knee function and symptoms over two years to see if repair can match or outperform reconstruction.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- arthroscopic ACL repair surgery
- What this could lead to
- If successful, ACL repair could become a standard option for certain tears, preserving the natural ligament and avoiding complications from reconstruction.
- What could go wrong
- This is a relatively small, early-stage trial. Repair may not be as durable as reconstruction, and only specific tear types are eligible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 140 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2022
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients with anterior cruciate ligament tear clearly identified by imaging or intraoperative microscope, Sherman grade I, II; planned surgery within 3 weeks after injury 2. Basic reading and writing skills, and barrier-free communication 3. A smartphone, can use WeChat or be able to learn 4. Patients give informed consent, and sign the informed consent form, and the process must meet the requirements of GCP Exclusion Criteria: 1. Combined with other knee joint injuries (posterior cruciate ligament injury, patellar dislocation, osteoarthritis, etc.) 2. Suffering from systemic immune diseases; 3. Existing other knee joint diseases or inflammatory diseases, including osteoarthritis, cervical spine disease, rheumatoid arthritis, fibromyalgia, polymyalgia rheumatica, etc. 4. Patients who have received local hormone injection within 3 months; 5. Those who have participated in clinical trials or are undergoing other clinical trials within 3 months before screening 6. Those who have serious primary cardiovascular disease, lung disease, endocrine and metabolic disease or serious diseases that affect their survival, such as tumor or AIDS, the researchers believe that they are not suitable for selection 7. Patients with severe liver disease, kidney disease, and hematological disease, such as renal function exceeding the upper limit of the normal value, and liver function exceeding 2 times the upper limit of the normal value; 8. Suffering from viral hepatitis, infectious diseases, severe abnormal blood coagulation mechanism and other Diseases that the researchers consider inappropriate for surgery 9. Women who are pregnant or breastfeeding, or who plan to become pregnant during the follow-up period, those who have a positive urine human chorionic gonadotropin test result before sampling; menstruating women should wait until the end of menstruation before surgery; 10. Severe neurological and mental disorders Disease patients; 11. Suspected or actual history of alcohol and drug abuse.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Second Affiliated Hospital, School of Medicine, Zhejiang University
RECRUITINGHangzhou, Zhejiang, 310000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a 3D-Printed gadget speed up knee recovery?
- Which tendon graft helps female athletes recover best after ACL surgery?
- Nerve block showdown: which technique eases ACL surgery pain best?
- Which ACL graft gets young athletes back in the game faster?
- Vibration therapy may reduce second ACL injury risk