ANTERIOR CRUCIATE LIGAMENT INJURIES

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This study compares two common tendon grafts used in ACL knee reconstruction: the quadriceps tendon and the patellar tendon. Researchers want to see which one gives better knee stability and function after surgery. The trial will enroll 100 people who need ACL surgery and follow …

This study tests whether a robot can help surgeons place bone tunnels more accurately during ACL reconstruction. Thirty patients with torn ACLs will receive standard surgery, but the robot guides where the tunnels are drilled. The main goal is to see if the robot's planned positi…

This study tests whether wearing a functional knee brace after ACL reconstruction helps athletes feel more ready to return to sports. 96 people aged 14-39 with a complete ACL tear who want to get back to sports will be enrolled. Half will wear a brace after surgery, half will not…

This study tests whether a platelet-rich plasma (PRP) injection, given soon after an ACL knee injury, can reduce inflammation and improve knee function. About 56 people with a recent ACL tear will receive either PRP or a placebo. The goal is to see if this treatment can lower the…

This study compares two different tendon grafts used to repair a torn ACL in the knee. Sixty adults with an isolated ACL injury will be randomly assigned to receive either a peroneus longus tendon graft or a hamstring tendon graft during arthroscopic surgery. The goal is to see w…

This study tests a wearable electrical stimulation sleeve called KneeStim in 60 military cadets recovering from ACL reconstruction. Half will use the device during rehab and daily tasks for 12 weeks, while the other half gets standard care with a low-intensity version. Researcher…

This study tests whether a concentrated bone marrow injection (cBMA) given during repeat ACL surgery can reduce knee pain and signs of arthritis. About 40 adults aged 18-55 who need a second ACL repair will receive either cBMA plus surgery or surgery alone. Researchers will track…

This study compares two surgical methods for repairing a torn ACL, the main knee ligament. Forty adults who need ACL surgery will be randomly assigned to receive either a single-bundle or double-bundle reconstruction, both combined with an extra ligament repair. Researchers will …

This study compares two common surgical grafts used to repair a torn anterior cruciate ligament (ACL): the semitendinosus hamstring tendon and the quadriceps tendon-bone graft. Researchers will enroll 200 active adults who recently tore their ACL and plan to return to sports. The…

This study tests a new type of MRI scanner called Magic Angle Directional Imaging (MADI) that can move around the patient to get clearer images of ligaments and tendons. Researchers will scan 20 adults scheduled for ACL repair surgery to see if MADI can diagnose tears more accura…

This study tests whether injecting a drug called anakinra into the knee within two weeks of an ACL injury can prevent arthritis that often develops years later. Half of the 32 participants will receive the drug, and half will receive a placebo (salt water). Researchers will track…

This study tests whether injecting morphine directly into the bone during ACL reconstruction can lower pain and reduce the need for opioid painkillers afterward. About 84 adults aged 18-40 having ACL surgery with a specific type of graft will be randomly assigned to get either th…

This study looks at whether whole-body vibration therapy can reduce knee pain in people who still have pain after ACL reconstruction surgery. About 50 adults aged 18 to 60 with ongoing kneecap pain will use a vibrating platform for 8 weeks. The goal is to see if this simple train…

This study looks at whether adding proprioceptive (body awareness) exercises to standard balance training helps people who had ACL surgery. Fifty adults aged 20-40, two weeks after surgery, will be split into two groups: one gets only standard balance exercises, the other adds pr…

This study looks at whether adding visual-guided balance training to standard rehab can improve knee function and walking patterns in people who had ACL reconstruction. 45 patients will be split into two groups: one doing standard rehab plus regular balance exercises, and the oth…

This study looks at whether adding blood flow restriction training (BFRT) to standard physical therapy helps teens recover strength and muscle size after ACL reconstruction. Forty teens who played sports before surgery will be randomly assigned to either standard rehab or standar…

This study tests whether combining graded exposure therapy with mindfulness meditation (via the Headspace app) can reduce injury-related fear and improve reaction time in people who had ACL reconstruction. Fifty participants aged 14-35, who are 6 months to 10 years post-surgery a…

This pilot study is testing whether increasing daily steps can improve knee cartilage health in people who have had ACL reconstruction. Fifty-six participants will wear a Fitbit and receive daily step goals via text for 16 weeks. Researchers will use MRI scans to measure changes …

This observational study will collect movement data from 5,000 healthy athletes aged 10 to 65 who play organized sports. Researchers will track participants for 12 months to see who gets injured, especially ACL tears. The goal is to build a database of normal movement patterns to…

This study follows 500 people who are already scheduled for routine shoulder or knee surgery for sports injuries. Researchers will track their recovery over two years using questionnaires about pain and function. The goal is to find out which factors—like injury type or surgical …

This study looks at 30 people who had ACL reconstruction surgery to see if having a knee extension deficit (not being able to fully straighten the knee) in the early weeks after surgery affects how well their thigh muscles recover strength. Participants are divided into two group…