Bone injection may cut opioid use after ACL surgery
NCT ID NCT06511232
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether injecting morphine directly into the bone during ACL reconstruction can lower pain and reduce the need for opioid painkillers afterward. About 84 adults aged 18-40 having ACL surgery with a specific type of graft will be randomly assigned to get either the bone injection or standard pain treatment. They will track their pain and medication use for two weeks and complete knee function surveys for up to 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
morphine
What this could lead to
If it works, this could offer a more targeted way to control pain after ACL surgery, potentially reducing the need for oral opioids.
What could go wrong
This is a small, early-phase study (84 people) testing a specific technique. It may not show a clear benefit over standard care, and intraosseous injection carries risks like infection or bone damage.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Houston Methodist Research Institute
RECRUITINGHouston, Texas, 77030, United States
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