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Which tendon graft helps female athletes recover best after ACL surgery?

NCT ID NCT07722104

Disease control Sponsor: Universidad Católica San Antonio de Murcia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study follows female athletes who undergo ACL reconstruction using either a hamstring tendon or a quadriceps tendon graft. Researchers track graft failure, return to sport, knee stability, and patient-reported outcomes for two years after surgery. The goal is to see whether one graft type leads to better recovery and function in this active population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ACL reconstruction using either hamstring tendon autograft or quadriceps tendon autograft
What this could lead to
If one graft type proves superior, it could guide surgeons toward better outcomes for female athletes recovering from ACL tears.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by surgeon preference or patient factors. Graft failure or complications remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 82 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Female athletes aged 16 to 35 years undergoing primary ACL reconstruction with either hamstring tendon or quadriceps tendon autograft across multiple sports medicine centers in Spain.

Ages

16 to 35 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 16 to 35 years with skeletal maturity * Active athlete: minimum two training sessions per week during the six months prior to injury in pivoting sports * Confirmed complete ACL rupture by MRI and clinical examination * Primary ACL reconstruction (first ligament surgery on the index knee) * Time from injury to surgery no longer than 6 months * Signed informed consent Exclusion Criteria: * Previous ligament surgery on either knee * Multiligament injury: simultaneous PCL, grade III MCL or LCL injury * Neuromuscular, rheumatological or systemic pathology interfering with rehabilitation or functional assessments * Pre-existing radiological osteoarthritis grade Kellgren-Lawrence ≥2 in the index knee * Inability to complete 24-month follow-up protocol * Pregnancy at inclusion or during follow-up period

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries Knee Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament injuries Knee injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • IMED Hospitales

    Alicante, Alicante, 03540, Spain

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