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Can Real-World data improve knee cartilage surgery outcomes?

NCT ID NCT07786207

Knowledge-focused Sponsor: Smith & Nephew, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This study is a large registry that collects information from adults undergoing knee surgery for cartilage damage. It tracks how different surgical procedures are used and how well they work in everyday clinical practice, not just in controlled trials. The goal is to build a comprehensive database that can support future research and improve understanding of knee cartilage repair outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Marketed Product - MP01 (a medical device for knee-joint surface lesions) and other surgical treatments
What this could lead to
If successful, this registry could provide valuable real-world evidence to guide surgeons in choosing the best cartilage repair procedures, potentially improving long-term knee function and recovery for patients.
What could go wrong
As an observational registry, it cannot prove which surgery is best, and results may be influenced by differences in patient characteristics and surgeon expertise. No new treatment is being tested, so direct patient benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2034

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants undergoing routine knee cartilage repair

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Prospective Subjects * Provides written informed consent. * Is eighteen (18) years of age or older at time of consent and considered skeletally mature in the opinion of the investigator. * Scheduled to undergo knee cartilage surgery with the Marketed Product-MP01 OR other knee cartilage repair surgery. * For subjects having other knee cartilage repair surgery: \- Falls within Marketed Product-MP01 on label indication: Knee chondral or osteochondral lesions (ICRS grade III and above, 1-7cm2) in patients with or without mild-moderate knee osteoarthritis (K/L 0-3). * Has an electronic device and is willing and able to use the device to complete the 'Electronic Clinical Outcomes Assessment' (eCOA). * Willing and able to complete all requested questionnaires. * Able to follow instructions and deemed capable of completing registry protocol requirements. Retrospective/Prospective Subjects * Provides written informed consent. * Was eighteen (18) years of age or older at time of surgery and considered skeletally mature at that time in the opinion of the investigator. * Underwent knee cartilage repair surgery with the Marketed Product-MP01 within the last 2-years. * Has an electronic device and is willing and able to use the device to complete the eCOA. * Willing and able to complete all requested questionnaires. * Able to follow instructions and deemed capable of completing registry protocol requirements. * Consents to retrospective data being collected from pre-operative visit(s) and surgery through to the point of consent as available in their medical notes. Exclusion Criteria: * History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate/coral derivatives. * Is actively participating in a cartilage repair clinical trial. * For subjects having other knee cartilage repair surgery: \- Treatment will be on patellar lesion(s). * Has participated previously in this registry (with the index or contralateral knee). * Meets the definition of a Vulnerable Subject per ISO 14155 Section 3.56.

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Conditions

The condition(s) this trial relates to.

Knee Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Joint surface knee lesions Knee injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CAO Research Foundation

    Washington D.C., District of Columbia, 20036, United States

  • Oklahoma Sports Science and Orthopedics

    Oklahoma City, Oklahoma, 73114, United States

  • The Orthopaedic Research Foundation, Inc.

    Indianapolis, Indiana, 46278, United States

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