One stitch or two? major trial tests simpler closure for heart valve procedure
NCT ID NCT06173115
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using one stitch device (Perclose) is as safe and effective as using two to close the leg artery after a minimally invasive heart valve replacement (TAVR) in people with severe aortic stenosis. About 876 participants will be randomly assigned to one of the two methods. The goal is to see if using a single device can reduce costs and procedure time without increasing complications like bleeding or artery damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SEVERE AORTIC STENOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beijing Anzhen Hospital, Capital Medical University
RECRUITINGBeijing, China
-
Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University
RECRUITINGHangzhou, Zhejiang, 310000, China
-
Fujian Provincial Hospital
RECRUITINGFuzhou, Fujian, China
-
Fuwai Central China Cardiovascular Hospital
RECRUITINGZhengzhou, Henan, China
-
Fuwai Hospital, Chinese Academy of Medical Sciences
RECRUITINGBeijing, China
-
General Hospital of Northern Theater Command, PLA
RECRUITINGShenyang, Liaoning, China
-
Henan Provincial Chest Hospital
RECRUITINGZhengzhou, Henan, China
-
Huzhou Central Hospital
RECRUITINGHuzhou, Zhejiang, China
-
Nanfang Hospital, Southern Medical University
RECRUITINGGuangzhou, Guangdong, China
-
Ningbo Medical Center Li Huili Hospital
RECRUITINGNingbo, Zhejiang, China
-
People's Hospital of Xinjiang Uygur Autonomous Region
RECRUITINGÜrümqi, Xinjiang, China
-
Qilu Hospital of Shandong University
RECRUITINGJinan, Shandong, China
-
Qingdao Municipal Hospital
RECRUITINGQingdao, Shandong, China
-
Sichuan Provincial People's Hospital
RECRUITINGChengdu, Sichuan, China
-
The Affiliated Hospital of Guangdong Medical University
RECRUITINGZhanjiang, Guangdong, China
-
The Affiliated Hospital of Qingdao University
RECRUITINGQingdao, Shandong, China
-
The First Affiliated Hospital of Bengbu Medical College
RECRUITINGBengbu, Anhui, China
-
The First Affiliated Hospital of Ningbo University
RECRUITINGNingbo, Zhejiang, China
-
The First Affiliated Hospital of Wenzhou Medical University
RECRUITINGWenzhou, Zhejiang, China
-
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITINGXi’an, Shanxi, China
-
The First Affiliated Hospital, Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, China
-
The First Hospital of Lanzhou University
RECRUITINGLanzhou, Gansu, China
-
The Second Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, China
-
Xiangya Hospital of Central South University
RECRUITINGChangshacun, Henan, China
-
Yulin First People's Hospital
RECRUITINGYulin, Guangxi, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A new heart valve without Open-Heart surgery: can it help High-Risk patients?
- Could a common blood pressure pill protect the heart after valve replacement?
- Heart valve unit may cut brain fog after procedure, study hopes
- AI-Powered ultrasound could replace CT for heart valve diagnosis
- New study aims to simplify care for patients with multiple leaky heart valves
- New registry to monitor Long-Term success of keyhole heart valve treatments