Promising cocktail aims to shrink esophageal tumors before surgery
NCT ID NCT06576973
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining the immunotherapy adbelimumab with chemotherapy and the targeted drug apatinib can help shrink esophageal tumors before surgery. About 35 adults with resectable esophageal squamous cell carcinoma will receive four cycles of the drug combo, then undergo surgery. The main goal is to see how many patients have no cancer left in the removed tissue.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- adbelimumab (immunotherapy), albumin paclitaxel, carboplatin, apatinib
- What this could lead to
- If successful, this combination could become a new pre-surgery treatment to shrink tumors and reduce recurrence risk in esophageal cancer patients.
- What could go wrong
- This is a small, early-phase trial with only 35 participants, so results may not apply broadly. The combination also carries risks of side effects from chemotherapy and immunotherapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
2nd Affiliated Hospital, School of Medicine, Zhejiang University
RECRUITINGHangzhou, China, 310009, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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