Engineered immune cells target stubborn abdominal cancer
NCT ID NCT07247396
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a personalized cell therapy (CAR-T cells) designed to attack a protein called CEA found on colorectal cancer cells. The therapy is given directly into the abdomen after surgery to remove visible tumors. The study will enroll 12 adults whose cancer has spread to the belly lining and who have not responded to standard treatments. The main goals are to check safety and find the best dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CEA-targeted CAR-T cells (a type of immune cell therapy)
What this could lead to
If it works, this could point toward a new treatment option for advanced colorectal cancer that has spread to the lining of the abdomen.
What could go wrong
This is a very early (Phase 1) trial with only 12 people, so it is mainly checking safety and dosing. The therapy may not shrink tumors or improve survival, and side effects like cytokine release syndrome are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 310017, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact