New mouthwash could fight gum disease without antibiotics

NCT ID NCT07402694

Not yet recruiting Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new mouthwash called Amphion can improve gum health when used after standard deep cleaning for periodontitis. Sixty adults with gum disease will receive either Amphion or a placebo mouthwash to use at home twice daily. The goal is to see if the mouthwash reduces plaque and gum bleeding better than cleaning alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Amphion mouthwash
What this could lead to: If it works, this could provide a new, antibiotic-free mouthwash option to help control plaque and gum inflammation after standard dental cleanings.
What could go wrong: This is a small, early-stage Phase 4 trial with only 60 participants. The mouthwash may not significantly improve outcomes over placebo, and long-term safety or effectiveness is not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MOUTHWASH PERIODONTITIS

Contacts and locations

Locations

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310000, China

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