New combo shows promise for Tough-to-Treat colorectal cancer

NCT ID NCT05171660

First seen Feb 17, 2026 · Last updated May 17, 2026 · Updated 14 times

Summary

This phase 3 trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy and a targeted therapy (bevacizumab) helps people with a specific type of advanced colorectal cancer (RAS-mutant, microsatellite stable) live longer without their cancer growing. The study includes 446 adults who have not had prior treatment for their metastatic disease. The goal is to see if the combination works better than the standard treatment alone.

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Contacts and locations

Locations

  • Xuefeng Fang

    Hangzhou, Zhejiang, 310009, China

Conditions

Explore the condition pages connected to this study.