Shockwave therapy may crack tough heart artery plaque

NCT ID NCT07340294

Ongoing Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using a shockwave device (intravascular lithotripsy) along with standard artery preparation can improve outcomes for people with moderate to severe coronary artery calcification. About 1,096 participants will be split into two groups: one gets standard prep alone, the other gets standard prep plus the shockwave. Researchers will track heart-related events over 24 months to see if the combo approach reduces the need for repeat procedures or prevents heart attacks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intravascular lithotripsy (shockwave device)
What this could lead to: If successful, this could offer a better way to treat hardened arteries in the heart, reducing the risk of heart attacks or repeat procedures.
What could go wrong: This is an early-stage study with no phase designation, so results are uncertain. The device may not improve outcomes over standard care, and there are risks like vessel injury or complications from the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

calcinosis coronary atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CALCIFIC CORONARY ARTERIOSCLEROSIS CORONARY ARTERY CALCIFICATION

Contacts and locations

Locations

Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China
The First Affiliated Hospital of Nanchang University (FAHNU)

Nanchang, Jiangxi, China
The People's Hospital of Liaoning Province

Shenyang, Liaoning, China
Tianjin Fourth Central Hospital

Tianjin, China

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