CROHN DISEASE

This study tested an oral medication called ozanimod to help people with moderate-to-severe Crohn's disease reach remission (fewer symptoms). About 625 adults with Crohn's who had not responded well to other treatments were randomly assigned to receive ozanimod or a placebo for 1…

This study tested the antifungal drug posaconazole in 10 adults with active Crohn's disease who carry a specific genetic risk factor (CARD9 S12N). The goal was to see if reducing gut fungi could improve inflammation and symptoms. The trial was terminated early, so results are lim…

This study looked at whether an anti-inflammatory whole-food diet can help people with mild-to-moderate Crohn's disease feel better and enter remission. Researchers planned to enroll 28 adults aged 18-75 with confirmed Crohn's. The study was terminated early, so results are limit…

This study tested whether the oral medication ozanimod could help people with moderate to severe Crohn's disease maintain symptom control over 52 weeks. About 550 participants who had already responded to an initial treatment were randomly assigned to receive ozanimod or a placeb…

This study tested a single injection of donor stem cells to treat fistulas (abnormal tunnels) in people with Crohn's disease who have an ileal pouch after colon removal. The goal was to see if the treatment was safe and could help close these hard-to-treat fistulas. The study was…

This study compared two surgical methods for removing diseased intestine in people with Crohn's disease to see which better prevents the disease from returning. It involved 13 adults who needed surgery for Crohn's that didn't respond to medication. The trial was stopped early, so…

This study tested whether adding an experimental daily pill (BI 706321) to the standard Crohn's drug ustekinumab could better control moderate to severe Crohn's disease. About 49 adults took either the combination or a placebo plus ustekinumab for 3 months, followed by ustekinuma…

This study looked at the long-term safety and effectiveness of the oral drug ozanimod for people with moderate to severe Crohn's disease. It was an extension study for participants who completed earlier studies. The study was terminated early, so results are limited.

This study tested whether a computer program could help doctors give the right dose of infliximab to children and young adults with Crohn's disease. The goal was to reach better drug levels in the blood compared to standard dosing. Only 6 people enrolled before the study was stop…

This early-stage trial tested whether stem cells from donated bone marrow could safely help heal perianal fistulas in people with Crohn's disease. The study involved 25 adults with stubborn fistulas that hadn't healed with other treatments. Researchers injected the stem cells dir…

This study tested whether a single injection of donor stem cells could safely heal rectovaginal fistulas in women with Crohn's disease. About 20 women were planned to receive the treatment and be monitored for side effects and healing. The trial was stopped early, so results are …

This study aimed to see if the antibiotic rifaximin could reduce bloating in people with diabetic gastroparesis, a condition where the stomach empties slowly. Researchers planned to measure symptom changes using a detailed questionnaire. However, the study was stopped early after…