CROHN DISEASE

This study looks at whether adding high-dose vitamin D3 to standard anti-TNF therapy can help control active inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placeb…

This study tests a new approach for people with Crohn's disease who have complex anal fistulas that did not heal with standard biologic drugs. Doctors take a small amount of the patient's own fat, break it into tiny pieces, and inject it around the fistula to help it close. The g…

This study looks at the long-term safety of the drug ustekinumab in children aged 2 to 18 with Crohn's disease, ulcerative colitis, or psoriatic arthritis. Participants must have already completed a previous ustekinumab study and shown benefit from the drug. The main goal is to m…

This study tests whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease. About 45 kids aged 8 to 16 who are already on anti-TNF medication will take the supplement for up to 48 weeks. The goal is to see if this…

This study tests a drug called guselkumab in 350 people with moderate to severe Crohn's disease who haven't responded well to other treatments. The goal is to see if it can reduce symptoms and heal the gut lining. Participants receive either the drug or a placebo, and researchers…

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. 123 adults starting a new oral or injectable treatment will use the system or standard care for 12 months. The goal is to see…

This study tests whether a plant-based resistant starch, tailored to each child's gut, can help restore a healthier gut microbiome in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for several months while researchers measur…

This study tests whether using a computer dashboard (iDose) to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 adults and teens will be followed for a year to see if the dashboard approach h…

This study tests whether a diet designed for Puerto Ricans with Crohn's disease can improve quality of life and reduce gut inflammation. About 150 adults with mild to moderate Crohn's will follow either the special diet or their usual diet for several weeks. The goal is to see if…

This study tests two different maintenance doses of the drug TEV-48574 given as a shot every 4 weeks. It includes 247 adults with moderate to severe ulcerative colitis or Crohn's disease who already completed a previous study. The goal is to see if the drug can keep symptoms unde…

This study tests a special diet called the Crohn's Disease Exclusion Diet (CDED) in adults with active Crohn's disease. One group gets the diet with a liquid supplement, while the other adds dairy back early. The goal is to see if the diet can reduce symptoms and gut inflammation…

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 100 children with Crohn's disease or ulcerative colitis. Participants must have mild disease or be in remission. The goal is to increase butyrate produc…

This study tests whether injecting a patient's own concentrated platelets (PRP) after balloon dilation can prevent the colon from narrowing again in people with Crohn's disease. About 74 adults with a short colon stricture will receive either a high or low concentration of PRP. T…

This study is testing a new, non-invasive imaging device called MSOT that uses light and sound to detect inflammation in the skin or gut. It includes 100 adults with graft-versus-host disease, Crohn's disease, or colitis. The main goal is to see if the device is safe and can help…

This early-phase study tests whether CoQ10 supplements can improve fatigue in people with Crohn's disease. About 60 participants will take one of two doses of CoQ10 for 8 weeks, and researchers will measure changes in fatigue and quality of life. The goal is to see if a larger, m…

This study follows 100 children with Crohn's disease to see how the condition affects them and which treatments are used in everyday medical practice. Researchers will track symptoms, treatment choices, and how well children improve over 14 and 54 weeks. The goal is to better und…

This study compares two ways of taking biopsies during colonoscopy in people with inflammatory bowel disease (IBD). About 1642 participants will be randomly assigned to either a limited biopsy approach or a more extensive random biopsy approach. The goal is to see which method fi…

This study looks at whether the probiotic VSL#3 can change how bile acids are processed in people with Crohn's disease or ulcerative colitis. About 79 adults with stable, inactive disease will take the probiotic for 6 weeks. Researchers will measure bile acid levels in blood and …

This study tests a program to help teenagers with Crohn's disease or ulcerative colitis move from pediatric to adult healthcare. About 90 teens aged 16 to 17.5 will either get the program (which includes a navigator, skills training, and education) or standard care. The goal is t…

This study checks if a thin tube placed through the nose can measure how leaky the gut is in healthy adults. Researchers will test if the device gives accurate readings and clear images. The goal is to see if this tool could help diagnose gut problems in the future.

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study takes small tissue samples from the gut during routine endoscopy and grows them into mini-organs called organoids. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goal is to learn how these dise…

This study compares a faster, contrast-free MRI technique (diffusion-weighted) with the standard MRI for monitoring Crohn's disease activity in 140 adults. The goal is to see if the simpler scan works just as well, without bowel cleansing or gadolinium injection, making follow-up…

This study looks at how diet and gut bacteria are linked to Crohn's disease in children. Researchers will follow 250 newly diagnosed children and 50 healthy kids, collecting stool, blood, and tissue samples along with diet logs. The goal is to create a computer algorithm that pre…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study is testing a special temperature probe that can be used during a routine colonoscopy to measure heat in the lining of the colon. The goal is to see if this tool can help detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and …

This study aims to create a detailed map of the cells in the gut of people with Crohn's disease compared to healthy individuals. Researchers will analyze tissue samples from 178 adults to see how cell types change with disease activity. The goal is to better understand what cause…