CROHN DISEASE

This study tests whether guselkumab, given as a shot under the skin, can help people with moderate to severe Crohn's disease achieve remission and heal their gut lining. About 350 adults who have not responded well to other treatments will receive either guselkumab or a placebo. …

This study follows 159 children aged 2 to 17 who have already completed a prior ustekinumab study for Crohn's disease, ulcerative colitis, or psoriatic arthritis. The goal is to collect long-term safety data by monitoring side effects, lab results, and injection-site reactions. P…

This study looks at whether people with Crohn's disease who are in remission can safely stop taking aminosalicylate (5-ASA) medication without their condition getting worse. About 334 participants will either continue or stop their 5-ASA therapy and be followed for 2 years to see…

This study tests two different doses of TEV-48574 (duvakitug) given as a shot every 4 weeks to adults with moderate to severe ulcerative colitis or Crohn's disease. Participants who completed a previous 14-week study can join. The goal is to see if the drug can keep the disease u…

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This study tests a support program for teens aged 16-17.5 with Crohn's disease or ulcerative colitis as they move from pediatric to adult healthcare. The program includes personalized assessments, a transition navigator, and virtual skill-building sessions. Researchers will measu…

This study looks at whether the probiotic VSL#3 can change how bile acids work in people with Crohn's disease or ulcerative colitis. About 79 participants will take two sachets of VSL#3 daily for six weeks. Researchers will measure bile acid levels in blood and stool to see if th…

This study tests whether a special anti-inflammatory diet, adapted to include traditional Puerto Rican foods, can help people with Crohn's disease feel better and reduce gut inflammation. About 150 adults with mild to moderate Crohn's will follow either the diet or their usual ea…

This study tests whether injecting a person's own processed fat tissue can heal complex anal fistulas caused by Crohn's disease that have not responded to standard treatments. About 80 adults with Crohn's and active fistulas will receive either the fat injection plus standard car…

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard treatment, with the goal …

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. About 123 adults starting a new oral or injectable treatment will use the system or get standard care for 12 months. The goal…

This pilot study tests whether a plant-based resistant starch, tailored to each child's gut bacteria, can improve gut health in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for a period, and researchers will measure change…

This study tests whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease. The goal is to see if this can help maintain remission and reduce the need for stronger medication. The study involves 45 children aged 8…

This study tests whether a plant-based starch, tailored to each child's needs, can help restore a healthier gut microbiome in children with inflammatory bowel disease (Crohn's or colitis). About 100 children with mild disease or in remission will receive the starch for 6 months. …

This study tests whether injecting a patient's own platelet-rich plasma (PRP) into the colon after balloon dilation can prevent the colon from narrowing again in people with Crohn's disease. About 74 participants will receive either a high or low concentration of PRP during the p…

This study tests two diet plans for adults with active Crohn's disease. One group follows the Crohn's Disease Exclusion Diet (CDED) with a liquid meal replacement, while the other adds dairy back early. The goal is to see if these diets can reduce symptoms and inflammation. The t…

This Phase 3 trial tests whether injecting a patient's own fat-derived stem cells, along with a glue, can close fistulas caused by Crohn's disease. 46 adults with Crohn's and at least one fistula are taking part. The main goal is to see if the fistula closes completely.

This study tests whether fecal microbiota transplant (FMT) capsules can help people with inflammatory bowel disease (IBD) who haven't improved on standard biologic drugs. 94 patients with mild-to-moderate Crohn's or ulcerative colitis will receive either FMT capsules plus a biolo…

This early-phase study tests whether taking CoQ10 supplements for 8 weeks can ease fatigue in people with Crohn's disease. About 60 adults with stable Crohn's will receive one of two doses, and researchers will track changes in fatigue and quality of life. The goal is to see if a…

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

This study tests whether listening to jazz or reggae music can reduce chronic pain in people with IBS, Crohn's disease, or colitis. Researchers will compare two groups: one listens to mindful jazz, the other to reggae, over four weeks. The goal is to find a safe, non-addictive wa…

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy. About 70 adults with permanent or long-term ostomies will take part in workshops and follow-up s…

This study looks at whether regular text message check-ins and the ability to text your IBD care team can improve disease management and quality of life. About 900 people with Crohn's disease or ulcerative colitis will take part. Some will get extra symptom surveys and texting ac…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy…

This pilot study is testing whether a deep learning algorithm can identify and score inflamed segments of the terminal ileum in MRI scans of people with Crohn's disease. Researchers will use 226 anonymized MRI scans, with radiologists first marking normal and abnormal areas. The …

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study follows 300 children to understand how diet, gut bacteria, and Crohn's disease interact. Researchers will collect stool, blood, and tissue samples, plus daily food logs via an app. The goal is to build a personalized algorithm that predicts how diet affects inflammatio…

This study looks at whether continuous heart rate variability (HRV) monitoring can predict how well patients with inflammatory bowel disease (IBD) respond to biologic therapies like infliximab or vedolizumab. Researchers will track HRV in 100 patients starting treatment and compa…

This study observes 562 adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are starting or switching to Hyrimoz®, a biosimilar of adalimumab. Researchers will track how many patients continue the treatment after 6 months and why some stop, such as …

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study compares a new, faster MRI technique (diffusion-weighted) to the standard MRI for monitoring Crohn's disease. The new method does not require a contrast injection or bowel cleansing, which patients often dislike. Researchers will check if the new scan is just as good a…

This study collects tissue samples from 178 adults with and without Crohn's disease to create a detailed map of gut cells. Researchers will compare cell types and activity between healthy and diseased tissue. The goal is to better understand what goes wrong in Crohn's and identif…

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This study follows 100 children with Crohn's disease to track their symptoms, treatments, and outcomes in everyday medical care. Researchers will look at how different therapies—like special diets, medications, or fecal transplants—affect disease activity over 14 to 54 weeks. The…