CROHN DISEASE

This study aims to collect long-term safety information for children and teenagers (ages 2 to 18) who are receiving ustekinumab injections for Crohn's disease, ulcerative colitis, or psoriatic arthritis. It is an extension study for participants who benefited from the drug in a p…

This study is testing whether two different doses of an experimental medication called TEV-48574 can help control symptoms of moderate to severe Crohn's disease or ulcerative colitis over the long term. The medication is given as an injection under the skin every four weeks. The …

This study is testing if adding an injection of a patient's own concentrated platelets (PRP) during a standard balloon stretching procedure helps keep narrowed sections of the colon open longer for people with Crohn's disease. The goal is to see if this combined approach can dela…

This study is testing whether injecting a patient's own processed fat tissue can heal stubborn perianal fistulas (painful tunnels near the anus) in people with Crohn's disease who haven't responded to standard biologic drugs. It aims to improve quality of life and reduce the need…

This study is testing whether a personalized type of resistant starch (a plant-based fiber) can help improve gut health in children with Crohn's disease or ulcerative colitis. Researchers want to see if this starch can promote healthier gut bacteria and reduce inflammation. The t…

This study is testing whether a specific type of dietary starch, chosen based on a child's unique gut bacteria, can help improve their gut health while they are on standard Crohn's medication. It involves 45 children aged 8-17 who have Crohn's disease in remission or with mild sy…

This study is testing whether a special anti-inflammatory diet, adapted to include traditional Puerto Rican foods, can help people with Crohn's disease feel better. 150 participants will either follow this new diet for 10 weeks or continue their usual eating habits. Researchers w…

This study is testing if a special, personalized type of plant-based starch can help control inflammatory bowel diseases (IBD) like Crohn's and ulcerative colitis in children. Researchers want to see if this starch, tailored to each child's gut bacteria, can reduce gut inflammati…

This study is testing whether a smartphone app and special 'smart' labels can help people with Crohn's disease or ulcerative colitis remember to take their medication. About 123 adults starting a new pill or injection treatment will use the app for a year. The goal is to see if t…

This study is testing whether regular text message check-ins and direct messaging with a medical team helps people with Crohn's disease or ulcerative colitis feel more confident managing their condition and achieve better health outcomes. It will involve 900 teenagers and adults …

This study is testing two versions of a special diet designed to help adults with active Crohn's disease. One group follows the diet while also drinking nutritional formula. The other group follows the diet but gets to reintroduce dairy products earlier. The goal is to see which …

This study is testing whether an injectable medication called guselkumab can help control symptoms and heal the gut in people with moderate-to-severe Crohn's disease. It involves about 350 participants whose current treatments aren't working well enough. The main goal is to see i…

This study is testing a new, simpler type of MRI scan to monitor inflammation in people with Crohn's disease. The goal is to see if this faster scan, which doesn't require a bowel-cleansing prep or an injection of contrast dye, works as well as the standard, more complex MRI scan…

This study is testing a new experimental imaging device called MSOT. It uses light and sound waves to take pictures of inflammation through the skin in people with Crohn's disease, colitis, or graft-versus-host disease. The main goal is to check if the device is safe and if its i…

This study is testing whether taking CoQ10, an over-the-counter supplement, can help reduce the severe fatigue often experienced by people with Crohn's disease. It will enroll 60 participants, including people with Crohn's and healthy volunteers, to compare two different doses ta…

This study aims to determine whether taking fewer random tissue samples during colonoscopy is just as effective at finding precancerous growths in people with long-term inflammatory bowel disease. Researchers will compare two different biopsy approaches in over 1,600 patients und…

This study aims to learn more about how Crohn's disease affects children by observing about 100 patients under 17 years old for up to two years. Researchers will track their symptoms, the different treatments their doctors prescribe, and how well they do over time. The goal is to…

This observational study aims to understand how diet and gut bacteria relate to Crohn's disease in children. Researchers will collect data from 300 children, including 250 newly diagnosed with Crohn's and 50 healthy children, to build a computer algorithm. The goal is to predict …

This study aims to understand how genetics, lifestyle, and other factors influence the progression and severity of many common chronic diseases. Researchers will collect health records, genetic data, and samples from 120,000 participants with conditions like diabetes, arthritis, …

This is a small, early-stage study to see if a new drug called AZD7798 changes inflammation in the intestines of people with Crohn's disease. Researchers will use special PET scans to take pictures inside the gut before and after treatment. The main goal is to gather information …

This study aims to create a detailed map of the cells in the gut of people with Crohn's disease. Researchers will analyze small tissue samples from about 178 adults, both with and without Crohn's, using advanced lab techniques. The goal is to understand how the disease changes th…

This study is testing a new tool—a thin probe inserted through the nose—to measure the health of the gut lining. Researchers want to see if this device can safely and accurately detect changes in 'gut permeability,' which is linked to conditions like Crohn's disease. The study in…