CROHN DISEASE

This study tested a medicine called spesolimab in 27 adults with Crohn's disease who also have fistulas near the anus. Participants received either the drug or a placebo every 4 weeks for 24 weeks. The goal was to see if the drug helps close fistulas and understand how it works. …

This study looked at how well a special diet (called CDED plus NEP) works for children aged 8 to 18 with active Crohn's disease in everyday medical practice. A total of 58 children took part. The goal was to see if the diet could help them feel better without needing steroids or …

This study involved 38 adults with inflammatory bowel disease (Crohn's or colitis) whose disease was under control with intravenous (IV) infliximab. Researchers switched them to a subcutaneous (under-the-skin) version of the same medication to see if drug levels, effectiveness, a…

This study looked at 150 adults with Crohn's disease who were treated with ustekinumab, a biologic drug. Researchers used special imaging scans to measure inflammation deep in the gut wall and checked if this helped predict how well the drug worked over 12 months. The goal was to…

This study tested the drug ustekinumab (STELARA) in 182 Chinese adults with moderate to severe Crohn's disease, a condition causing inflammation in the digestive tract. The goal was to see if the drug could reduce symptoms and heal gut damage over 52 weeks. Participants received …

This study tested whether eating grape powder every day could improve gut health in adults with Crohn's disease, a type of inflammatory bowel disease. Twenty-one participants in remission took grape powder for a period, and researchers measured changes in their gut bacteria and m…

This study tested a medicine called ustekinumab in 101 children with moderate to severe Crohn's disease. The goal was to see if the drug could reduce symptoms and keep the disease under control. Children first received the drug through an IV, then some continued with injections. …

This study looked at 688 people with ulcerative colitis or Crohn's disease who received Vedolizumab (Kynteles) as part of their normal care in South Korea. The main goal was to track side effects and see how many patients felt better after treatment. Vedolizumab helps control inf…

This study tested a new drug called tulisokibart (PRA023) in 55 people with moderate to severe Crohn's disease. The goal was to see if the drug is safe and can improve symptoms and gut healing. Participants who finished the first 12 weeks could continue treatment for up to 170 we…

This study tested a new approach for people newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers used a blood test that measures proteins to identify patients at high risk for a worse disease course. These high-risk …

This study looked at 108 adults with Crohn's disease whose symptoms returned while on standard ustekinumab treatment. Researchers tested whether giving a stronger re-induction dose followed by maintenance every 4 weeks (instead of every 8 weeks) could bring back remission. The go…

This study tested a new drug called TEV-48574 in 290 adults with moderate to severe ulcerative colitis or Crohn's disease. The goal was to see if the drug could reduce inflammation and bring about remission after 14 weeks of treatment. Participants received one of two doses or a …

This study tested whether using a non-invasive device (ClearSight) to monitor blood flow and guide fluid management during colorectal surgery could lower the chance of complications. 160 adults having colorectal surgery for polyps, cancer, or Crohn's disease took part. The approa…

This study tested whether taking fecal microbiota transplant (FMT) capsules could help prevent Crohn's disease from returning after surgery. 23 adults who had surgery for Crohn's received FMT either by capsules or colonoscopy. The goal was to see if the capsules could deliver hel…

This study looked at whether switching from a lower to a higher concentration of adalimumab (AVT-02) reduces injection site pain and improves treatment adherence. It involved 324 adults with conditions like Crohn's disease, rheumatoid arthritis, or psoriasis. Researchers measured…

This study looked at whether a physical activity program could help improve bone density in children and teenagers with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Kids with IBD often have lower bone density due to inflammation, medication, or…

This study looked at whether a short-term, plant-based low-calorie diet (called a fasting mimicking diet) could improve depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild to moderate depression and IBD completed three 5-day diet cycles. Resea…

This small study tested whether a digital wellness app using artificial intelligence and virtual reality could safely provide mental health support to adults with inflammatory bowel disease who also have mild anxiety or depression. Twenty-two participants used the app during a si…

This study tested a self-management program for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Researchers wanted to …

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (IBD) to understand how DNA that escapes from cells might worsen inflammation. Researchers analyzed blood, stool, and gut tissue samples to study a specific pathway called cGAS-STING. The goal was to id…

This study looked at 11 adults with Crohn's disease who had surgery to remove damaged parts of their intestine. Researchers compared two surgical methods to see how each affected the bacteria living in the gut and the immune system in the intestine. The goal was to understand bio…

This study looked at 300 people with Crohn's disease to see if medical imaging could help predict who would need surgery within the first year after diagnosis. The researchers created a computer model using radiomics—a way to analyze images for hidden patterns. The goal is to hel…

This study looked at physical fitness in 100 children aged 10-17 with chronic inflammatory bowel disease (like Crohn's or ulcerative colitis) and compared them to healthy children of the same age, size, and sex. Researchers measured things like heart-lung fitness, muscle strength…

This study looked at 63 Crohn's disease patients who had anal fistulas treated with anti-TNF drugs and seton drainage. The goal was to see how often fistulas came back over the long term and what factors might increase the risk of recurrence. The findings could help doctors impro…

This study looked at how well two newer biologic drugs, Ustekinumab and Vedolizumab, work for people with Crohn's disease in China. Researchers tracked 50 patients to see if the drugs helped heal the gut and reduce symptoms, and also checked for side effects. The goal was to gath…

This study looked at whether differences in the BAFF gene are linked to getting Crohn's disease or how the disease behaves. Researchers compared 824 people with and without Crohn's. They found no new treatments, but the results may help understand the disease better.

This study tested whether a quicker MRI without contrast dye can detect Crohn's disease as well as the standard MRI that requires an injection. Researchers looked at scans from 250 patients to see if the simpler method could tell a normal from an abnormal exam. The goal is to mak…

This study tested a new drug (AZD7798) in 9 adults with Crohn's disease to see how it changes inflammation in the small intestine. Researchers used special PET scans to measure these changes. The goal was to understand how the drug works in the body, not to treat the disease dire…

This study looked at 59 adults with Crohn's disease who had surgery to remove damaged parts of their intestine. Researchers tracked changes in certain immune cells (T cells) in the blood and gut over one year to see if they could predict when the disease would come back. The goal…