CROHN DISEASE

This study looked at how well a specific dietary plan works for children with active Crohn's disease in real-world settings. It combined a special Crohn's Disease Exclusion Diet (CDED) with partial liquid nutrition (PEN). The main goal was to see if this diet could help children …

This small pilot study tested whether eating grape powder every day could change the mix of gut bacteria in people with Crohn's disease. For 21 days, 21 adults with Crohn's in remission consumed the powder, which is equal to about 1.5 cups of fresh grapes. Researchers measured ch…

This study tested whether taking fecal transplant capsules works as well as receiving it via colonoscopy to prevent Crohn's disease from returning after surgery. Researchers compared the two methods in 23 people with Crohn's who had recent bowel surgery. The goal was to see if th…

This study tested whether a medicine called spesolimab could help adults with Crohn's disease who have painful fistulas near the anus. Twenty-seven participants were randomly assigned to receive either the drug or a placebo via an IV drip every four weeks for 24 weeks. Doctors tr…

This study tested an investigational drug, TEV-48574, to see if it could help control two serious inflammatory bowel diseases: Crohn's disease and ulcerative colitis. For 14 weeks, 290 adults with moderate-to-severe disease received one of two doses or a placebo to see which was …

This study tested whether a medication called ustekinumab could help children with moderate to severe Crohn's disease get their symptoms under control and stay in remission. It involved 101 young participants who first received the drug through an IV and then through injections. …

This study tested whether a guided physical activity program could improve bone mineral density in children and teenagers with chronic inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Researchers worked with 15 young patients who had IBD for at least six m…

This study looked at whether switching patients with stable Crohn's disease or ulcerative colitis from receiving their infliximab medicine through an IV at a clinic to giving themselves a shot at home was effective. It followed 38 adult patients for 24 weeks after the switch to s…

This study tested whether using a blood test to identify newly diagnosed inflammatory bowel disease (IBD) patients at high risk for severe disease could improve their outcomes. 300 patients were randomly assigned to either have their treatment guided by this blood test result or …

This study tested how well and how safely the medication ustekinumab (brand name STELARA) works for Chinese adults with moderate to severe Crohn's disease. It involved 182 participants who received the treatment for one year. Researchers measured whether the drug reduced gut infl…

This study monitored patients with ulcerative colitis or Crohn's disease in South Korea who were treated with vedolizumab (Kynteles injection) as part of their regular care. The main goals were to track side effects and see how many patients' symptoms improved while using this al…

This study tested whether a faster, injection-free MRI scan could be as good as the standard scan at finding signs of Crohn's disease. The goal was to make the test shorter and more comfortable for patients, as the standard scan can be long and the drink needed to prepare for it …

This small, exploratory study tested a single session using a virtual reality app with an AI-powered guide to provide mental health support. It involved 22 adults with inflammatory bowel disease (IBD) who also had mild to moderate anxiety or depression. The main goal was to see i…

This study looked at whether switching patients to a higher concentration version of the drug adalimumab (brand name SIMLANDI™) causes less injection site pain than the standard version. It involved 324 adults in Canada who were already using adalimumab for conditions like Crohn'…

This study tested whether a special plant-based, low-calorie 'fasting mimicking' diet could help reduce depression symptoms in people with Crohn's disease or ulcerative colitis (IBD). 42 adult participants with mild-to-moderate depression tried three cycles of the 5-day diet. Res…

This study tested a new self-management program designed to help people with Crohn's disease or ulcerative colitis. The program taught 55 participants strategies for tracking symptoms, managing stress and pain, improving sleep, and adjusting diet. Researchers wanted to see if the…

This study aimed to understand why inflammatory bowel diseases (IBD) like Crohn's and colitis are often more severe in children. Researchers tested the idea that DNA leaking from cells might trigger and worsen gut inflammation through a specific biological pathway. They analyzed …

This study aimed to understand if certain variations in a gene called BAFF are connected to who gets Crohn's disease and how severe it becomes. Researchers compared 310 people with Crohn's disease to 514 healthy individuals, looking at their genetic makeup. The goal was to gather…

This study aimed to understand how two different surgical techniques for reconnecting the intestines affect the community of gut bacteria and the local immune system in people with Crohn's disease. Researchers compared the 'Kono-S' procedure to a standard method by analyzing tiss…

This study aimed to understand why Crohn's disease often returns after surgery. Researchers followed 59 patients who had intestinal surgery for Crohn's, tracking their immune cells for one year. The goal was to find biological markers that could predict which patients are at high…