CROHN DISEASE

This study looked at 108 adults with Crohn's disease whose symptoms returned while on standard ustekinumab treatment. Researchers gave them a re-induction infusion and then split them into two groups: one continued the usual shot every 8 weeks, the other got a shot every 4 weeks.…

This study tested the drug upadacitinib in people with Crohn's disease that only affects the small bowel, a type that is often harder to treat. Researchers compared 3 patients with small-bowel Crohn's to others with Crohn's in different areas, using ultrasound to measure bowel in…

This study looked at 150 adults with Crohn's disease to see if advanced imaging could predict how well the drug Ustekinumab controls inflammation. Researchers measured changes in the gut wall and compared them to standard tests. The goal was to improve treatment monitoring for th…

This study tested a new drug called tulisokibart (PRA023) in 55 people with moderate-to-severe Crohn's disease who had not responded well to other treatments. The main goals were to check safety and see if the drug could improve gut healing and reduce symptoms. After 12 weeks, so…

This study tested whether a device that uses light to monitor blood flow (photoplethysmography) could help doctors manage fluids better during colorectal surgery. The goal was to reduce complications after surgery. 160 adults having colorectal surgery took part. The approach is n…

This phase 2b trial tested a new drug called TEV-48574 (duvakitug) in 290 adults with moderate to severe ulcerative colitis or Crohn's disease. The study aimed to see if the drug could help patients achieve clinical remission (for UC) or an endoscopic response (for CD) after 14 w…

This study tested whether a daily dose of grape powder (46 grams) could improve gut bacteria and reduce inflammation in adults with Crohn's disease who were in remission. Twenty-one participants took the grape powder and provided stool and blood samples. The goal was to see if gr…

This study tested switching 38 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) from intravenous infliximab to a subcutaneous (under-the-skin) injection. Researchers measured drug levels, quality of life, and patient satisfaction over 24 weeks. The goal was …

This study monitored 688 people in South Korea with ulcerative colitis, Crohn's disease, or pouchitis who were treated with Kynteles (vedolizumab) as part of their normal care. The main goal was to track side effects, and researchers also looked at how many patients saw symptom i…

This study tested whether a blood test measuring proteins can help doctors choose the best treatment for people newly diagnosed with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. 300 patients were split into two groups: one where doctors had …

This study tested whether ustekinumab, a drug that blocks inflammation, can help children aged 2 to 17 with moderate-to-severe Crohn's disease. 101 participants first received the drug through an IV, then some continued with injections while others got a placebo. The goal was to …

This study tested a drug called spesolimab in 27 adults with Crohn's disease who also have fistulas near the anus. The drug is given by IV every 4 weeks for 24 weeks. The study had two parts: first, researchers took tissue samples to learn what causes the fistulas; second, they c…

This study looked at how well a special diet (called CDED plus NEP) works for children aged 8 to 18 with active Crohn's disease. The diet aims to reduce inflammation and help the gut heal without needing steroids or other strong drugs. Researchers tracked 58 kids in real-world cl…

This study looked at 73 adults with Crohn's disease who needed surgery to remove a diseased part of the bowel. Researchers compared two different ways to reconnect the healthy ends: one that removes the fatty tissue around the bowel (mesentery) and one that keeps it (Kono-S). The…

This study tested the drug ustekinumab (STELARA) in 182 Chinese adults with moderate-to-severe Crohn's disease. The goal was to see if the drug could reduce symptoms and heal the gut lining over 52 weeks. Participants received the drug by IV and later by injection, and researcher…

This study tested two team-based care models for 657 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) who also had mild to severe behavioral health symptoms. One model used in-person visits with a team including a gastroenterologist, nurse, nutritionist, and…

This study compares contrast-enhanced ultrasound to standard CT and MRI scans for detecting bowel inflammation in children aged 10–18 with Crohn's disease. Participants receive an ultrasound with a microbubble contrast agent alongside their regularly scheduled CT or MRI. The goal…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study tested whether a quick MRI without contrast injection can spot signs of Crohn's disease as well as the standard MRI with contrast. 250 patients were scanned using both methods, and radiologists compared the results. If the injection-free approach works, it could make f…

This study looked at four substances in the blood (Osteoprotegerin, sRANKL, NFkB, and TFF3) to see if they could help diagnose inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers measured these markers in 70 newly diagnosed patient…

This study tested whether a diet that avoids certain inflammatory foods could lower the risk of developing Crohn's disease in healthy people who have a close relative with the condition. Twenty-nine participants followed the 'Tasty & Healthy' diet for 8 weeks. The main goal was t…

This early study tested whether giving people with Crohn's disease a fecal transplant (FMT) after surgery could help prevent the disease from coming back. 23 adults who had surgery for Crohn's received FMT either by capsules or colonoscopy. The goal was to see if the capsules cou…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This study looked at whether a tailored physical activity program could improve bone density in 15 children and teens with inflammatory bowel disease (IBD). Kids with IBD often have weaker bones due to inflammation, medication, and lower activity levels. The program focused on mo…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study tested whether a low-calorie, plant-based diet that mimics fasting could reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD followed either the fasting-mimicking diet or a calorie-sufficient pl…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This study investigates whether analyzing bowel sounds with a computer can help measure disease activity in children with Crohn's disease. Researchers will record bowel sounds and compare them to a standard disease activity score. The goal is to find a noninvasive, painless way t…

This study looked at how a soy-based diet or a similar diet without soy changes gut bacteria in people with Crohn's disease (in remission or active) and healthy volunteers. Researchers measured inflammation markers and tracked whether symptoms stayed stable over one week. The goa…

This study looked at 343 adults who were diagnosed with inflammatory bowel disease (Crohn's disease or ulcerative colitis) before age 17. Researchers compared their employment rates and education levels to the general population to understand how the disease may affect long-term …

This completed study looked at 63 Crohn's disease patients who had an anal fistula treated with anti-TNF drugs and a seton drain. Researchers tracked how long the fistula stayed closed and what factors might cause it to come back. The goal is to better understand long-term outcom…

This completed Italian study looked at how often children with inactive inflammatory bowel disease (IBD) also have disorders of gut-brain interaction (DGBIs), like irritable bowel syndrome. Researchers used the Rome IV questionnaire to compare 220 children with quiescent IBD to h…

This completed study looked at 300 Crohn's disease patients to see if CT scan images could predict who would need surgery within a year of diagnosis. Researchers built a computer model using 'radiomics' to analyze the scans. The goal is to help doctors start stronger treatments e…

This completed study from China looked at 50 adults with Crohn's disease who were treated with two newer biologic drugs, Ustekinumab and Vedolizumab. The goal was to see how well these drugs control the disease and what factors might predict a good response. By analyzing past med…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at 120 adults with inflammatory bowel disease (IBD) to see if simple stool tests can tell if the disease is active or in remission, just like a colonoscopy does. Colonoscopy is the current gold standard but is expensive, invasive, and not ideal for frequent chec…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This small, early-stage study tested whether a new drug called AZD7798 changes how a special imaging tracer binds to the gut in people with Crohn's disease. Nine adults with active Crohn's disease involving the small intestine received multiple doses of AZD7798 and underwent PET …

This study aims to create a tool that helps nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). The research involved 792 participants, including men with IBD and their partners, as well as healthcare professionals. The goal is …

This study analyzed data from over 8,700 pregnant women with inflammatory bowel disease (Crohn's or ulcerative colitis) to see how well doctors follow guidelines when prescribing antiTNFα drugs and whether the benefits outweigh the risks for both mother and baby. Researchers look…

This completed study looked at whether certain gene variations (BAFF) are linked to the risk and features of Crohn's disease. Researchers compared 824 people with and without the disease. The goal was to better understand the genetic factors involved, which could guide future res…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This study looked at 59 adults with Crohn's disease who had surgery to remove diseased parts of their intestine. The goal was to see if certain immune cells in the blood and gut could predict whether the disease would come back within a year. By understanding these patterns, doct…

This study looked at tiny, lab-grown versions of the intestine called organoids, made from tissue samples of people with inflammatory bowel disease (Crohn's or ulcerative colitis), a genetic polyp condition (FAP), and healthy volunteers. The goal was to understand how intestinal …

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This study looked at 11 adults with Crohn's disease who had surgery to remove damaged parts of their intestine. Researchers compared two surgical methods—Kono-S and standard side-to-side—to see how each affected the gut's bacteria and immune cells. The goal was to gather clues ab…

This study takes small tissue samples from people with inflammatory bowel disease (IBD) and healthy volunteers to grow 'mini guts' (organoids) in the lab. Researchers will then expose these organoids to radiation to mimic radiation enteritis and test potential treatments. The goa…

This study looked at 150 adults with Crohn's disease who had narrowings in the small intestine (strictures) but no symptoms. Researchers reviewed medical records to see how often these silent strictures later caused problems like belly pain, nausea, or vomiting. The goal is to he…