Could a simple ultrasound replace risky scans for kids with Crohn's?

NCT ID NCT03492944

Completed Diagnosis Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares contrast-enhanced ultrasound to standard CT and MRI scans for detecting bowel inflammation in children aged 10–18 with Crohn's disease. Participants receive an ultrasound with a microbubble contrast agent alongside their regularly scheduled CT or MRI. The goal is to see if the ultrasound can accurately identify and measure inflammation, potentially offering a safer, radiation-free alternative for monitoring disease activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ultrasound Microbubble Contrast Agent (Lumason)
What this could lead to: If ultrasound works as well as CT or MRI, children with Crohn's could avoid radiation and sedation during routine scans.
What could go wrong: This is a small early study (25 children) comparing imaging methods, not testing a treatment. Ultrasound may not be as accurate as standard scans.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE

Contacts and locations

Locations

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

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