CROHN DISEASE

This study will test hyperbaric oxygen therapy (HBOT) in 100 people with various conditions, including long COVID, Crohn's disease, frostbite, and more. HBOT involves breathing pure oxygen in a pressurized chamber to help the body heal. The goal is to see if HBOT improves quality…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard biologic therapy helps more adults with Crohn's disease achieve complete gut healing. About 185 participants in China will be randomly assigned to receive either the diet plus biologics or…

This study will follow 50 people with moderate to severe Crohn's disease or ulcerative colitis to see how long the drug guselkumab keeps working in everyday medical practice. Researchers will measure how long patients stay on the treatment and how quickly they feel better. The go…

This study tests a blood-filtering device (Efferon LPS) in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone or st…

This study tests a drug called mirikizumab in 60 adults with Crohn's disease who have inflammatory narrowing (strictures) in the small intestine. The goal is to see if the drug can shrink the narrowed area and improve symptoms. Participants will receive the drug and be monitored …

This study tests a drug called risankizumab for people with a severe form of Crohn's disease that causes scarring and narrowing of the intestines. About 260 adults who have not improved with standard treatments will receive either the drug or a placebo. The goal is to see if the …

This study tests whether adding a new drug (LY4395089) to an existing treatment (mirikizumab) works better than mirikizumab alone for adults with moderate-to-severe Crohn's disease. About 60 participants will be followed for 62 weeks to check bowel healing and symptom control. Th…

This study will follow about 100 adults in Saudi Arabia who have moderate to severe Crohn's disease or ulcerative colitis and are starting the drug guselkumab. Researchers want to see how long patients continue their treatment in everyday medical practice. The study does not give…

This study tests whether adding a special nutritional drink (LH VIOLA) to standard dietary advice helps people with inflammatory bowel disease (IBD) who are at risk of malnutrition. About 146 adults with Crohn's disease or ulcerative colitis will either receive counseling alone o…

This study tests whether a special day hospital program helps people with inflammatory bowel disease (IBD) better manage their condition. About 240 adults with Crohn's disease or ulcerative colitis will receive a single visit that combines blood tests, a doctor check, education, …

This study is testing several different new treatments for adults with moderate to severe ulcerative colitis or Crohn's disease. Participants will be assigned to one of the specific treatment studies and receive either the new treatment or a comparison treatment for at least 62 w…

This study will follow 100 adults who need a stoma (an opening in the belly to pass waste) after bowel surgery. Researchers want to see if patients who get stoma education and marking before surgery have a better quality of life and fewer problems than those who do not. The study…

This study is developing a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will interview patients and test the questionnaire with 275 adults to make sure it is accurate and reliable. The goal is to give doct…

This study tests whether a self-management program can improve health and quality of life for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The program focuses on changing behaviors to help manage the condition. The study will enr…