CROHN DISEASE

This study is testing several new treatments for adults with moderate-to-severe ulcerative colitis or Crohn's disease who haven't responded well to current medications. Participants will be assigned to different treatment groups within a larger master study framework. The goal is…

This study is testing a new 'one-stop' clinic day for people with Crohn's disease or ulcerative colitis. During a single hospital visit, patients receive blood tests, doctor consultations, education sessions, and other specialized care all together. Researchers want to see if thi…

This study is testing two biologic drugs, risankizumab and ustekinumab, for people with a severe form of Crohn's disease where the intestines develop scar tissue and narrow. It's for patients whose current treatments have stopped working. The goal is to see if these drugs can pre…

This study is testing whether adding a new drug called LY4395089 to an existing Crohn's disease medication (mirikizumab) works better than the existing medication alone. The trial will involve 60 adults with moderate to severe Crohn's disease and will last about 62 weeks. Researc…

This study is testing whether adding a special nutritional drink to standard dietary advice helps people with Crohn's disease or ulcerative colitis (IBD) who are at risk of malnutrition. About 146 participants will be randomly assigned to receive either just dietary counseling or…

This study aims to find out which newer medications work best and are safest for children with inflammatory bowel disease (IBD) when standard anti-TNF drugs have stopped working. It will follow about 1100 children and teens who are already starting one of these newer medications …

This study is gathering information to see how well hyperbaric oxygen therapy (HBOT) works for over 40 different health conditions. It will enroll about 100 people who have been referred for HBOT for conditions like Long COVID, Crohn's disease, and various ulcers. The main goal i…

This study is testing whether the medication mirikizumab can reduce inflammation and improve symptoms in people with Crohn's disease who have developed painful, narrowed sections of intestine called strictures. About 60 adults in the US and Canada will receive the drug for 24 wee…

This study aims to see if the drug guselkumab can help control Crohn's disease in Chinese patients who initially responded to ustekinumab but then lost that benefit. It will involve 78 participants and will measure improvements in symptoms and intestinal healing over 48 weeks. Th…

This study is testing a medical device that filters harmful substances from the blood to help calm severe flare-ups of Crohn's disease and ulcerative colitis. It will compare patients receiving standard therapy alone to those receiving standard therapy plus the blood-filtering tr…

This study is testing a new self-management program designed to help people with active Crohn's disease or ulcerative colitis. Researchers want to see if teaching patients specific skills and behaviors can improve their quality of life and health outcomes. The main goal of this s…

This study aims to see if meeting with a stoma nurse or surgeon for education and planning before getting a bowel diversion stoma (a surgical opening in the abdomen for waste) leads to fewer complications and a better quality of life. It will observe 100 patients, comparing those…

This study aims to learn if areas of bowel inflammation in people with Crohn's disease or ulcerative colitis are warmer than healthy tissue. During a standard colonoscopy, researchers will use a special temperature probe to measure heat inside the colon. The goal is to gather inf…