Crohn's surgery showdown: which technique wins?

NCT ID NCT04578392

Terminated Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two surgical methods for removing diseased intestine in people with Crohn's disease: one that cuts the main artery high up, and one that spares the mesentery (the tissue holding the intestine). The goal was to see which technique better prevents the disease from coming back within 6 months. Only 13 adults with limited Crohn's disease took part before the study was stopped early.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical procedure (high ligation vs. mesenteric sparing ileocolic resection)
What this could lead to: If successful, this could help identify a better surgical approach to reduce the chance of Crohn's disease returning after surgery.
What could go wrong: The trial was terminated early with very few participants (13), so results are limited and may not be reliable. It is unclear if either technique is truly better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE

Contacts and locations

Locations

Cedars-Sinai Hospital System

Los Angeles, California, 90048, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cleveland Clinic Florida

Weston, Florida, 33331, United States
Humanitas

Rozzano, Milano, 20089, Italy
Mt. Sinai

Toronto, Ontario, M5G 1X5, Canada
St Mark's Hospital and Academic Institution

Harrow, Middlesex, HA1 3UJ, United Kingdom
Stanford University School of Medicine

Stanford, California, 94305, United States

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