Stem cells tested for tough Crohn's fistulas – but trial stopped early
NCT ID NCT04519684
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether stem cells from donated bone marrow could heal fistulas (abnormal tunnels) in people with Crohn's disease who had a pouch after colon removal. The trial planned to enroll 24 adults but was terminated early, so we don't have clear results on safety or healing. The approach aimed to offer a less invasive option than repeat surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- allogeneic bone marrow derived mesenchymal stem cells
- What this could lead to
- If it worked, this could offer a new way to heal fistulas in Crohn's disease of the pouch, possibly avoiding more surgery or a permanent ostomy.
- What could go wrong
- The trial was terminated early, so we don't have enough data to know if it's safe or effective. It was also a small, early-phase study, so results may not apply widely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cleveland Clinic
Cleveland, Ohio, 44195, United States
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