Stem cells tested for tough Crohn's fistulas – but trial stopped early
NCT ID NCT04519684
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether stem cells from donated bone marrow could heal fistulas (abnormal tunnels) in people with Crohn's disease who had a pouch after colon removal. The trial planned to enroll 24 adults but was terminated early, so we don't have clear results on safety or healing. The approach aimed to offer a less invasive option than repeat surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
allogeneic bone marrow derived mesenchymal stem cells
What this could lead to
If it worked, this could offer a new way to heal fistulas in Crohn's disease of the pouch, possibly avoiding more surgery or a permanent ostomy.
What could go wrong
The trial was terminated early, so we don't have enough data to know if it's safe or effective. It was also a small, early-phase study, so results may not apply widely.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic
Cleveland, Ohio, 44195, United States