New study aims to unlock why Anti-TNF drugs heal some Kids' Crohn's but not others

NCT ID NCT05781152

Recruiting now Disease control Sponsor: Connecticut Children's Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 900 children ages 6-17 who are newly diagnosed with Crohn's disease and starting anti-TNF therapy. Researchers will track healing of the intestine using blood tests, stool samples, colonoscopy, and MRI over one year. The goal is to understand why some children heal completely while others do not, so doctors can personalize treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Anti-TNF therapy (biologic drugs like Remicade, Humira)
What this could lead to: If successful, this could help doctors personalize anti-TNF treatment for children with Crohn's, leading to better healing of the intestine.
What could go wrong: This is an observational study, not testing a new drug. It won't prove that anti-TNF works better than other treatments, and results may not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease inflammatory bowel disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE

Contacts and locations

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Cedars-Sinai
RECRUITING

Los Angeles, California, 90048, United States
Children's Hospital Western Ontario
RECRUITING

London, Ontario, N6A 5W9, Canada
Children's Hospital of Eastern Ontario
RECRUITING

Ottawa, Ontario, K1H 8L1, Canada
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19146, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Cohen Children's Medical Center of NY
RECRUITING

Lake Success, New York, 11042, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Connecticut Children's Medical Center
RECRUITING

Hartford, Connecticut, 06106, United States
Emory University
RECRUITING

Atlanta, Georgia, 30328, United States
Goryeb Children's Hospital/Morristown Medical Center/Atlantic Children's Health
RECRUITING

Morristown, New Jersey, 07960, United States
Levine Children's
RECRUITING

Charlotte, North Carolina, 28203, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Rady Children's Hospital - San Diego and University of California, San Diego
ACTIVE_NOT_RECRUITING

San Diego, California, 92123, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Riley Hospital for Children at Indiana University Health
RECRUITING

Indianapolis, Indiana, 46202, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Stollery Children's Hospital
RECRUITING

Edmonton, Alberta, T6G 1C9, Canada
The Johns Hopkins Children's Medical Center
RECRUITING

Baltimore, Maryland, 21287, United States
Toronto SickKids Hospital
RECRUITING

Toronto, Ontario, M5G1X8, Canada
UCSF Benioff Children's Hospitals
RECRUITING

San Francisco, California, 94158, United States
UH/Rainbow Babies and Children's Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
UPMC Children's Hospital of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

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