New study aims to unlock why Anti-TNF drugs heal some Kids' Crohn's but not others
NCT ID NCT05781152
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows 900 children ages 6-17 who are newly diagnosed with Crohn's disease and starting anti-TNF therapy. Researchers will track healing of the intestine using blood tests, stool samples, colonoscopy, and MRI over one year. The goal is to understand why some children heal completely while others do not, so doctors can personalize treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Anti-TNF therapy (biologic drugs like Remicade, Humira)
What this could lead to
If successful, this could help doctors personalize anti-TNF treatment for children with Crohn's, leading to better healing of the intestine.
What could go wrong
This is an observational study, not testing a new drug. It won't prove that anti-TNF works better than other treatments, and results may not apply to all children.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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Cedars-Sinai
RECRUITINGLos Angeles, California, 90048, United States
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Children's Hospital Western Ontario
RECRUITINGLondon, Ontario, N6A 5W9, Canada
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Children's Hospital of Eastern Ontario
RECRUITINGOttawa, Ontario, K1H 8L1, Canada
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19146, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Cohen Children's Medical Center of NY
RECRUITINGLake Success, New York, 11042, United States
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Columbia University Medical Center
RECRUITINGNew York, New York, 10032, United States
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Connecticut Children's Medical Center
RECRUITINGHartford, Connecticut, 06106, United States
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Emory University
RECRUITINGAtlanta, Georgia, 30328, United States
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Goryeb Children's Hospital/Morristown Medical Center/Atlantic Children's Health
RECRUITINGMorristown, New Jersey, 07960, United States
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Levine Children's
RECRUITINGCharlotte, North Carolina, 28203, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Rady Children's Hospital - San Diego and University of California, San Diego
ACTIVE_NOT_RECRUITINGSan Diego, California, 92123, United States
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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Riley Hospital for Children at Indiana University Health
RECRUITINGIndianapolis, Indiana, 46202, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Stollery Children's Hospital
RECRUITINGEdmonton, Alberta, T6G 1C9, Canada
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The Johns Hopkins Children's Medical Center
RECRUITINGBaltimore, Maryland, 21287, United States
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Toronto SickKids Hospital
RECRUITINGToronto, Ontario, M5G1X8, Canada
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UCSF Benioff Children's Hospitals
RECRUITINGSan Francisco, California, 94158, United States
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UH/Rainbow Babies and Children's Hospital
RECRUITINGCleveland, Ohio, 44106, United States
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UPMC Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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