New scan could help Crohn's patients avoid unnecessary surgery
NCT ID NCT06252493
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a special PET/MR scan that uses a radioactive tracer to detect scar tissue in the bowel of people with Crohn's disease. The goal is to see if the scan can tell the difference between scarred (fibrotic) strictures and inflamed ones, which would help doctors decide whether surgery or medication is the better option. Twenty-five adults with Crohn's disease who are already scheduled for possible surgery will receive the tracer and undergo the scan, and the results will be compared with what surgeons find during the operation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Gallium-68 labeled collagen binding probe 8 ([68Ga]CBP8)
What this could lead to
If successful, this scan could help doctors decide which Crohn's patients need surgery and which can be treated with medication, avoiding unnecessary operations.
What could go wrong
This is a very small, early study with only 25 people. The tracer may not clearly distinguish scar from inflammation in all cases, and results may not apply to everyone with Crohn's disease.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
RECRUITINGCharlestown, Massachusetts, 02129, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••