Head-to-Head drug battle aims to tame Crohn's Flare-Ups

NCT ID NCT07499232

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests whether guselkumab works better than risankizumab for people with moderate to severe Crohn's disease. About 530 adults will receive one of the two drugs and be followed for a year. The goal is to see which drug leads to deeper remission, meaning fewer symptoms and less gut inflammation.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CROHN DISEASE

Contacts and locations

Locations

A O U Sant Orsola Malpighi
RECRUITING

Bologna, 40138, Italy
Aarhus University Hospital
RECRUITING

Aarhus C, 8200, Denmark
Akademiska Sjukhuset
RECRUITING

Uppsala, 751 85, Sweden
Algemeen Ziekenhuis Delta
RECRUITING

Roeselare, 8800, Belgium
Aphm - Hopital Nord
RECRUITING

Marseille, 13015, France
Aphp Hopital Saint Antoine
RECRUITING

Paris, 75012, France
Azienda Ospedaliero Universitaria San Martino
RECRUITING

Genova, 16132, Italy
Azienda Sanitaria dell'Alto Adige - Ospedale di Bolzano
RECRUITING

Bolzano, 39100, Italy
Barts Health NHS Trust
RECRUITING

Greater London, E1 2AJ, United Kingdom
Biodax Medical Research Trials
RECRUITING

Miami, Florida, 33186, United States
Bispebjerg Hospital
RECRUITING

København NV, 2400, Denmark
CHU Amiens Picardie
RECRUITING

Amiens, 80000, France
CHU Nantes - Hotel Dieu
RECRUITING

Nantes, 44000, France
CHU Nimes
RECRUITING

Nîmes, 30900, France
CHU de Liege
RECRUITING

Liège, 4000, Belgium
CHU de Reims
RECRUITING

Reims, 51100, France
Centre Hospitalier Universitaire de Nancy - Hôpital Central
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Centre Hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Centrum Medyczne 'Medyk' Sp. z o.o. K.
RECRUITING

Rzeszów, 35-326, Poland
Centrum Medyczne Medis ManerMed Sp Z O O
RECRUITING

Bydgoszcz, 85 229, Poland
Centrum Medyczne Plejady
RECRUITING

Krakow, 30363, Poland
Centrum Medyczne Promed
RECRUITING

Krakow, 31-513, Poland
Changzhou No 2 Peoples Hospital
RECRUITING

Changzhou, 213018, China
Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin (CBF)
RECRUITING

Berlin, 12203, Germany
Charlotte Gastroenterology and Hepatology, PLLC
RECRUITING

Charlotte, North Carolina, 28207, United States
Charlton Digestive Disease Centre
RECRUITING

Hamilton, Ontario, L8N1Y2, Canada
Chelsea And Westminster Hospital
RECRUITING

London, SW10 9NH, United Kingdom
Clermont Ferrand University Hospital
RECRUITING

Clermont-Ferrand, 63000, France
Clinexpert Gyongyos Kft
RECRUITING

Gyöngyös, 3200, Hungary
Cliniq s.r.o.
RECRUITING

Bratislava, 811 09, Slovakia
Clinique Ambroise Pare
RECRUITING

Neuilly-sur-Seine, 92200, France
Clinique IMD
RECRUITING

Montreal, Quebec, H3H1E3, Canada
Cliniques Universitaires Saint Luc
RECRUITING

Brussels, 1200, Belgium
Clinnova Research
RECRUITING

Anaheim, California, 92805, United States
Cotton-O'Neil Clinical Research Center
RECRUITING

Topeka, Kansas, 66606, United States
DFW Clinical Trials
RECRUITING

Carrollton, Texas, 75010, United States
Digestive Disease Specialists Inc
RECRUITING

Oklahoma City, Oklahoma, 73114, United States
Digestive Health Specialists of the Southeast
RECRUITING

Dothan, Alabama, 36305, United States
ENDOMED s.r.o
RECRUITING

Košice, 040 13, Slovakia
East View Medical Research
RECRUITING

Mobile, Alabama, 36608, United States
Endomedix
RECRUITING

Budapest, 1139, Hungary
Ersta sjukhus
RECRUITING

Stockholm, 116 30, Sweden
FNsP F. D. Roosevelta Banska Bystrica
RECRUITING

Banská Bystrica, 975 17, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky
RECRUITING

Nové Zámky, 940 34, Slovakia
Fakultni Nemocnice Ostrava
RECRUITING

Ostrava-Poruba, 708 00, Czechia
Fakultni Thomayerova nemocnice
RECRUITING

Prague, 14000, Czechia
Fakultni nemocnice Kralovske Vinohrady
RECRUITING

Prague, 100 00, Czechia
Fondazione Policlinico Universitario A Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Frontier Clinical Research
RECRUITING

Uniontown, Pennsylvania, 15401, United States
GASTRO I. s.r.o.
RECRUITING

Prešov, 080 01, Slovakia
GASTRO-Studien
RECRUITING

Berlin, 10825, Germany
GASTROMED Kopon Zmudzinski i wspolnicy SP j Specjalistyczne Centrum Gastrologii i Endoskopii
RECRUITING

Torun, 87 100, Poland
GCP Clinical Research
RECRUITING

Tampa, Florida, 33609, United States
GI Pros Research
RECRUITING

Naples, Florida, 34102, United States
GIRI Gastrointestinal Research Institute
RECRUITING

Vancouver, British Columbia, V6Z 2K5, Canada
Gastro LM s.r.o.
RECRUITING

Prešov, 080 01, Slovakia
Gastroenterologie, s.r.o., Hradec Kralove
RECRUITING

Hradec Kralova, 500 02, Czechia
Gastroenterology Associates of Central GA
RECRUITING

Macon, Georgia, 31201, United States
Gastroenterology Clinic of Acadiana
RECRUITING

Lafayette, Louisiana, 70503, United States
Gastroenterology Research of America, LLC
RECRUITING

San Antonio, Texas, 78229, United States
Ghent University Hospital
RECRUITING

Ghent, 9000, Belgium
Great Lakes Gastroenterology Research, LLC
RECRUITING

Mentor, Ohio, 44060, United States
Green Leaf Clinical Trials
RECRUITING

Jacksonville, Florida, 32258, United States
Hepato-gastroenterologie HK, s.r.o.
RECRUITING

Hradec Králové, 500 12, Czechia
Herlev Hospital
RECRUITING

Herlev, 2730, Denmark
Hoag Memorial Hospital
SUSPENDED

Newport Beach, California, 92663, United States
Hosp. Arquitecto Marcide
RECRUITING

Ferrol, 15405, Spain
Hosp. Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hosp. Clinico Univ. de Santiago
RECRUITING

Santiago de Compostela, 15706, Spain
Hosp. Gral. Univ. Dr. Balmis
RECRUITING

Alicante, 03010, Spain
Hosp. Univ. Dr. Josep Trueta
RECRUITING

Girona, 17007, Spain
Hosp. Univ. de Torrejon
RECRUITING

Madrid, 28850, Spain
Hosp. Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hosp. de Navarra
RECRUITING

Navarra, 31008, Spain
Hospices Civils de Lyon CHU Lyon Sud
RECRUITING

Pierre-Bénite, 69495, France
Hvidovre Hospital
RECRUITING

Hvidovre, 2650, Denmark
IRCCS Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Imperial College London
RECRUITING

London, W120HS, United Kingdom
Institut Prive MICI Clinique des Cedres
RECRUITING

Échirolles, 38130, France
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Karolinska Universitetssjukhuset
RECRUITING

Stockholm, 171 76, Sweden
Klinikum Wels Grieskirchen
RECRUITING

Wels, 4600, Austria
Klinikum rechts der Isar der TU Munchen
RECRUITING

München, 81675, Germany
Krankenhaus der Barmherzigen Brüder
RECRUITING

Vienna, 1020, Austria
LKH - Universitätsklinikum der PMU Salzburg
RECRUITING

Salzburg, 5020, Austria
LKH-Univ. Klinikum Graz
RECRUITING

Graz, 8036, Austria
Linkoping University Hospital
RECRUITING

Linköping, 58185, Sweden
London Digestive Disease Institute
RECRUITING

London, Ontario, N6K 1M6, Canada
London North West University Healthcare NHS Trust
RECRUITING

Greater London, NW10 7NS, United Kingdom
Lubbock Gastroenterology
RECRUITING

Lubbock, Texas, 79424, United States
Maastricht UMC
RECRUITING

Maastricht, 6229 HX, Netherlands
Medical Associates Research Group, Inc.
RECRUITING

San Diego, California, 92123, United States
Medical Network Sp z o o
RECRUITING

Warsaw, 04 501, Poland
Medical Research Center of Connecticut
RECRUITING

Hamden, Connecticut, 06518, United States
Medizinische Universitatsklinik Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Michigan Center of Medical Research
RECRUITING

Farmington Hills, Michigan, 48334, United States
Morehouse School of Medicine
RECRUITING

Atlanta, Georgia, 30310, United States
NAU New Aalborg University Hospital
RECRUITING

Gistrup, 9260, Denmark
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
RECRUITING

Warsaw, 02-781, Poland
New Cross Hospital
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom
New York Gastroenterology Associates
RECRUITING

New York, New York, 10075, United States
Nordsjaellands Hospital, Hillerod
RECRUITING

Hilleroed, 3400, Denmark
Norfolk and Norwich University Hospital
RECRUITING

Norwich, NR4 7UQ, United Kingdom
Obudai Egeszsegugyi Centrum Kft
RECRUITING

Budapest, 1036, Hungary
Odense UH og Svendberg sygehus
RECRUITING

Odense C, 5000, Denmark
Ospedale Mauriziano Torino
RECRUITING

Torino, 10128, Italy
Palmetto Primary and Specialty Care Physicians, Charleston
RECRUITING

Summerville, South Carolina, 29486, United States
Pannónia Magánorvosi Centrum Kft
RECRUITING

Budapest, H-1136, Hungary
Peak Gastroenterology Associates
RECRUITING

Colorado Springs, Colorado, 80907, United States
Praxiszentrum Fur Gastroenterologie und Endoskopie Grevenbroich
RECRUITING

Grevenbroich, 41515, Germany
Radboud Umcn
RECRUITING

Nijmegen, 6525 GA, Netherlands
Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom
Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus
RECRUITING

Mölndal, 431 30, Sweden
Sanchez Clinical Research, Inc
RECRUITING

Miami, Florida, 33157-6575, United States
Semmelweis Egyetem
RECRUITING

Budapest, 1088, Hungary
Semmelweis Egyetem 1
RECRUITING

Budapest, 1082, Hungary
Semmelweis Egyetem 2
RECRUITING

Budapest, 1083, Hungary
Sodersjukhuset
RECRUITING

Stockholm, 118 83, Sweden
Southern Star Research Institute, LLC
RECRUITING

San Antonio, Texas, 78229, United States
St. Elisabeth Ziekenhuis
RECRUITING

Tilburg, 5022 GC, Netherlands
St. Marien und St. Annastiftskrankenhaus
RECRUITING

Ludwigshafen am Rhein, 67067, Germany
Sydvestjysk Sygehus
RECRUITING

Esbjerg, 6700, Denmark
Szegedi Tudomanyegyetem
RECRUITING

Szeged, 6725, Hungary
TLC Clinical Research Inc
RECRUITING

Los Angeles, California, 90048, United States
Taunton Surgical Centre
RECRUITING

Oshawa, Ontario, L1J 0C7, Canada
The Second Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, 510261, China
The Sixth Affiliated Hospital Sun Yat sen University
RECRUITING

Guangzhou, 510655, China
The University of Texas Health Science Center at Tyler
RECRUITING

Tyler, Texas, 75708, United States
Toronto Immune and Digestive Health Institute Inc
RECRUITING

Toronto, Ontario, M6A 3B4, Canada
Twoja Przychodnia - Szczecinskie Centrum Medyczne
RECRUITING

Szczecin, 71-434, Poland
United Gastroenterologists
RECRUITING

Los Alamitos, California, 90720, United States
Universitaetsklinikum Mannheim
RECRUITING

Mannheim, 68167, Germany
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium
Universitatsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitatsklinikum Jena
RECRUITING

Jena, 07747, Germany
Universitatsklinikum Schleswig Holstein Kiel
RECRUITING

Kiel, 24105, Germany
Universitatsklinikum Wiener Neustadt
RECRUITING

Wiener Neustadt, 2700, Austria
University College London Hospitals Nhs Foundation Trust
RECRUITING

London, NW1 2PG, United Kingdom
Vojenska nemocnice Brno
RECRUITING

Brno, 636 00, Czechia
Vseobecna nemocnica Rimavska Sobota
RECRUITING

Rimavská Sobota, 979 12, Slovakia
West Middlesex University Hospital
RECRUITING

Iselworth, TW7 6AF, United Kingdom
Westchester Putnam Gastroenterology
RECRUITING

Carmel, New York, 10512, United States
Zhongda Hospital Southeast University
RECRUITING

Nanjing, 210009, China
Ziekenhuis Oost-Limburg
RECRUITING

Genk, 3600, Belgium

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