Pacemaker tweak may help heart failure patients breathe easier during exercise

NCT ID NCT07270536

Recruiting now Symptom relief Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether increasing the pacemaker rate during light exercise can lower pressure inside the heart for people with heart failure with preserved ejection fraction (HFpEF). Twenty participants will have their heart pressures measured at rest and while cycling, as the pacemaker rate is gradually increased. If successful, this could lead to a simple, drug-free way to reduce breathlessness and fatigue.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: accelerated pacing with AV-delay optimization
What this could lead to: If it works, this could offer a simple, drug-free way to improve daily functioning and comfort for HFpEF patients with pacemakers.
What could go wrong: This is a very small, early study (20 participants) measuring immediate effects only. It may not translate to long-term benefits or apply to all HFpEF patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HFPEF

Contacts and locations

Locations

Jessa Ziekenhuis Hasselt
RECRUITING

Hasselt, 3500, Belgium
University Hospitals Leuven
RECRUITING

Leuven, 3000, Belgium

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