New drug cocktail aims to ease dual Heart-Lung condition

NCT ID NCT07147114

Recruiting now Disease control Sponsor: Gachon University Gil Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding macitentan to the standard drug dapagliflozin improves outcomes for people with heart failure and a specific type of high blood pressure in the lungs. 64 adults in South Korea will take either the combo or dapagliflozin alone for 24 weeks. Researchers will measure changes in lung pressure, heart strain, walking ability, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: macitentan and dapagliflozin combination
What this could lead to: If successful, this could point to a more effective treatment for heart failure patients with a specific type of pulmonary hypertension, potentially improving heart function and quality of life.
What could go wrong: This is a small, early-phase (Phase 4) exploratory trial with only 64 participants. The combination may not show significant benefit over standard care, and side effects from the drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

craniofacial microsomia diastolic heart failure pulmonary hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMBINED PRE- AND POST-CAPILLARY PULMONARY HYPERTENSION CPCPH GROUP 2 PULMONARY HYPERTENSION HFMREF HFPEF

Contacts and locations

Locations

Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Chonnam National University Hospital
RECRUITING

Gwangju, 61469, South Korea
Chungbuk National University Hospital
NOT_YET_RECRUITING

Chungju, 28644, South Korea
Chungnam National University Hospital
RECRUITING

Daejeon, 35015, South Korea
Gachon University Gil Hospital
RECRUITING

Incheon, 405-760, South Korea
Incheon Sejong Hospital
NOT_YET_RECRUITING

Incheon, 21080, South Korea
Keimyung University Dongsan Hospital
RECRUITING

Daegu, 42601, South Korea
Koera University Guro Hospital
NOT_YET_RECRUITING

Seoul, 08308, South Korea
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
Pusan National University Yangsan Hospital
NOT_YET_RECRUITING

Yangsan, 50612, South Korea
Samsung Medical Center
NOT_YET_RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
The Catholic University of Korea, Seoul St.Mary
RECRUITING

Seoul, 06591, South Korea
Yonsei University Health System, Severance Hospital
NOT_YET_RECRUITING

Seoul, 03722, South Korea
Yonsei University, Wonju Severance Christian Hospital
RECRUITING

Wŏnju, 26426, South Korea

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