HFPEF
Clinical trials for HFPEF explained in plain language.
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Triple drug combo aims to reverse heart scarring in stiff heart failure
Disease control Recruiting nowThis study tests whether a three-drug combination (SGLT2 inhibitor, ARNI, and MRA) can improve heart structure, function, and symptoms in 50 people with advanced HFpEF, a type of heart failure where the heart is stiff but pumps normally. Participants will receive either the tripl…
Matched conditions: HFPEF
Phase: PHASE2 • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New drug cocktail aims to ease dual Heart-Lung condition
Disease control Recruiting nowThis study tests whether adding macitentan to the standard drug dapagliflozin improves outcomes for people with heart failure and a specific type of high blood pressure in the lungs. 64 adults in South Korea will take either the combo or dapagliflozin alone for 24 weeks. Research…
Matched conditions: HFPEF
Phase: PHASE4 • Sponsor: Gachon University Gil Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Pacemaker tweak may help heart failure patients breathe easier during exercise
Symptom relief Recruiting nowThis study tests whether increasing the pacemaker rate during light exercise can lower pressure inside the heart for people with heart failure with preserved ejection fraction (HFpEF). Twenty participants will have their heart pressures measured at rest and while cycling, as the …
Matched conditions: HFPEF
Phase: NA • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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Veterans' heart failure study tests simple knee exercise fix
Knowledge-focused Recruiting nowThis study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then have the veterans do 8 weeks of knee exercises to see if i…
Matched conditions: HFPEF
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Heart failure clues: study tracks 500 patients for 3 years
Knowledge-focused Recruiting nowThis study follows 500 people with a type of heart failure called HFpEF (heart failure with preserved ejection fraction) for at least 3 years. Researchers want to find out which medical signs or test results can predict serious problems like hospitalization or death. No new treat…
Matched conditions: HFPEF
Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:09 UTC