HFPEF
Clinical trials for HFPEF explained in plain language.
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New drug combo aims to ease double Heart-Lung strain
Disease control Recruiting nowThis study tests whether adding a second drug (macitentan) to a standard heart failure medicine (dapagliflozin) works better than the standard medicine alone. About 64 adults in South Korea with heart failure and a specific type of high blood pressure in the lungs will take the p…
Matched conditions: HFPEF
Phase: PHASE4 • Sponsor: Gachon University Gil Medical Center • Aim: Disease control
Last updated May 17, 2026 04:15 UTC
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New triple therapy aims to reverse heart damage in stiff heart condition
Disease control Recruiting nowThis study tests whether a combination of three heart medications (SGLT2 inhibitor, ARNI, and MRA) can improve heart structure, function, and daily life in people with advanced heart failure with preserved ejection fraction (HFpEF). Fifty participants will receive either the trip…
Matched conditions: HFPEF
Phase: PHASE2 • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Disease control
Last updated May 17, 2026 04:13 UTC
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Pacemaker tweak may ease breathing in heart failure patients
Symptom relief Recruiting nowThis study looks at whether changing the pacemaker settings during light exercise can lower pressure in the heart and improve symptoms like shortness of breath in people with a type of heart failure called HFpEF. About 20 adults with HFpEF who already have a pacemaker will take p…
Matched conditions: HFPEF
Phase: NA • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Symptom relief
Last updated May 17, 2026 04:17 UTC
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Can knee exercises boost blood flow in veterans with heart failure?
Knowledge-focused Recruiting nowThis study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then test whether 8 weeks of knee exercises can improve blood f…
Matched conditions: HFPEF
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 17, 2026 04:14 UTC
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Can we predict heart failure worsening? new study seeks answers
Knowledge-focused Recruiting nowThis study follows 500 people with a type of heart failure called HFpEF over at least 3 years. Researchers want to find out which medical tests or body signals best predict serious problems like hospitalization or death. Participants had detailed heart exams, including exercise t…
Matched conditions: HFPEF
Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Knowledge-focused
Last updated May 17, 2026 04:13 UTC