Universitaire Ziekenhuizen Ku Leuven

This study follows 1,600 people with type 1 diabetes, including young children aged 2-6, who use hybrid closed-loop insulin pumps (Medtronic, Tandem, or Omnipod). These devices automatically adjust insulin based on blood sugar readings but still require users to enter meal inform…

This study is testing a custom-made metal knee implant called Episealer for people with cartilage damage in the knee. The implant is designed based on each patient's MRI scan. Researchers are following a small group of patients for up to 10 years to see if the implant stays in pl…

This study tests whether rinsing the nose with a xylitol solution can reduce sinus symptoms in adults with cystic fibrosis. Participants will use both xylitol and standard saline rinses at different times to compare effects. The goal is to see if xylitol, a natural sugar alcohol,…

The FATLAS study is looking at how body fat (adiposity) influences breast cancer at both the whole-body and cellular levels. Researchers will enroll 150 breast cancer patients with different body types (lean, overweight, obese) and collect blood, tumor tissue, and body measuremen…

This study tests a camera that uses different colors of light to tell the difference between low-grade brain tumor tissue and normal brain tissue during surgery. Ten adults with suspected low-grade glioma will have the camera used during their tumor removal operation. The goal is…

This study looks back at the medical records of 600 adults who received a single shot of morphine into the spine before surgery. The goal is to understand how often side effects like breathing problems, itching, and nausea happen. By learning more, doctors hope to make pain manag…

This study looks at 40 people with early-stage Huntington's disease and healthy volunteers to see how well two types of brain scans can detect changes over 2 years. Participants get PET and MRI scans plus clinical exams at the start and after 2 years. The goal is to find better w…

This study looks back at the medical records of 1,891 adults who received a kidney transplant at a Belgian hospital between 2004 and 2022. Researchers are collecting routine clinical and lab data to find patterns that predict transplant rejection or failure. The goal is to build …

This study tests whether using an ultrasound measure of heart muscle coordination (mechanical dyssynchrony) can better select heart failure patients for cardiac resynchronization therapy (CRT) than current guidelines. About 500 patients will receive a CRT device, but pacing will …

This study examines how different patient characteristics and treatments influence the value of care for adult spinal deformity. Researchers will measure health outcomes and costs in 140 patients treated at University Hospitals Leuven. The goal is to understand what leads to bett…

This study looks at three different knee replacement designs: one that keeps the ACL, one that substitutes for it, and one that sacrifices it. Researchers want to see which design gives the best function, pain relief, and satisfaction in 75 people with severe knee arthritis. Part…

This study follows 88 working-age adults (63 or younger) who had knee replacement surgery to see when and how many return to work. Researchers track pain, knee function, and work ability using questionnaires over 1.5 years. The goal is to identify factors that help or hinder retu…

This study looks at why people with severe liver disease who are in the intensive care unit (ICU) are at risk for a dangerous fungal lung infection called invasive pulmonary aspergillosis. Researchers will study 450 patients to find better ways to predict, diagnose, and treat thi…

This study looks at whether general anesthesia given to pregnant women for surgery might affect their child's intelligence and brain development. Researchers will compare children who were exposed to anesthesia before birth with those who were not. The goal is to understand any l…

This study uses donated placentas from healthy pregnancies to measure how much sugammadex, a drug used to reverse anesthesia, passes from mother to baby. Researchers will test drug levels in both the maternal and fetal sides of the placenta in a lab model. The goal is to provide …

This study uses in-depth interviews to explore how people with implantable cardioverter-defibrillators (ICDs) and their partners cope emotionally, socially, and physically. Researchers aim to uncover unmet needs and barriers to care that surveys often miss. By talking directly to…

This study follows 400 people who have or are getting an implantable cardioverter-defibrillator (ICD) to see how their quality of life changes over up to 12 years. Participants fill out questionnaires about physical and emotional health, device acceptance, and concerns about acti…