Can vitamin a derivative shield immune system during cancer radiation?
NCT ID NCT06439888
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a drug called ATRA (a form of vitamin A) to standard radiation therapy can prevent a drop in infection-fighting white blood cells in people with a few metastatic tumors. About 58 adults with solid cancers that have spread to up to 5 spots will receive radiation to all visible tumors, with or without ATRA pills taken for 3 days every 3 weeks. The goal is to see if the combination is safe and reduces the risk of low lymphocyte counts, which can weaken the immune system.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- all-trans retinoic acid (ATRA, also known as tretinoin) plus stereotactic body radiation therapy (SBRT)
- What this could lead to
- If successful, this approach could reduce a common side effect of radiation (low white blood cell counts) and potentially improve cancer control in patients with a few metastatic spots.
- What could go wrong
- This is an early-phase trial with only 58 participants, so results may not apply broadly. ATRA can cause side effects like skin dryness or headache, and the combination may not work as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OLIGOMETASTATIC DISEASE are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Centre Léon Bérard
NOT_YET_RECRUITINGLyon, 69000, France
-
Gustave Roussy
RECRUITINGVillejuif, 94800, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Zinc-Based compound fight cancer?
- Can a pill that starves tumors of oxygen help fight advanced cancer?
- Can a new drug shrink Hard-to-Treat solid tumors?
- New imaging agent aims to light up hidden tumors
- Cancer-Killing virus injected directly into tumors shows promise in Mid-Stage trial
- New scan could reveal hidden cancer cells