Could everyday aspirin and statins fight advanced prostate cancer?

NCT ID NCT03819101

Recruiting now Disease control Sponsor: Gustave Roussy, Cancer Campus, Grand Paris Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether taking aspirin and atorvastatin (a common cholesterol-lowering drug) can help men with castrate-resistant prostate cancer live longer. The study plans to enroll 1210 participants who are starting their first treatment for this advanced stage. Researchers will compare survival rates between those taking the drugs and those not, to see if this simple combination offers a benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetylsalicylic acid (aspirin) and atorvastatin (a statin)
What this could lead to: If it works, this could offer a simple, low-cost way to extend survival for men with advanced prostate cancer that no longer responds to hormone therapy.
What could go wrong: This is a large phase 3 trial, but the drugs are already widely used for other conditions; their benefit for prostate cancer is unproven. There is a risk of side effects like bleeding or muscle pain.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

AYADI
NOT_YET_RECRUITING

Tunis, Tunisia
Bellinzona Istituto Oncologico
ACTIVE_NOT_RECRUITING

Bellinzona, 6500, Switzerland
CH Roanne
NOT_YET_RECRUITING

Roanne, 42300, France
CHU Besançon Hopital Jean Minjoz
RECRUITING

Besançon, 25000, France
CHU Martinique -Hôpital Clarac
RECRUITING

Fort de France, 97261, France
CHU Poitiers
NOT_YET_RECRUITING

Poitiers, 86000, France
CHU de Pointe à Pitre Abymes
RECRUITING

Guadeloupe, 97139, France
Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France
Centre Azuréen de Cancérologie
RECRUITING

Mougins, 06250, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, 63011, France
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
NOT_YET_RECRUITING

Milan, Cosenza, Italy
Gustave Roussy Cancer Campus Grand Paris
RECRUITING

Villejuif, Val de Marne, 94805, France
Hôpital Foch
RECRUITING

Suresnes, 92151, France
Hôpital NOVO
RECRUITING

Cergy-Pontoise, 95303, France
Hôpital Privé Drôme Ardèche
NOT_YET_RECRUITING

Valence, 26000, France
Hôpital d'Instruction des Armées Bégin
RECRUITING

Saint-Mandé, 94160, France
Hôpital de la Croix Saint Simon
RECRUITING

Paris, 75960, France
Hôpitaux Du Léman
RECRUITING

Thonon-les-Bains, 74200, France
Institut Jean Godinot
RECRUITING

Reims, 51726, France
Institut de Cancérologie Lucien Neuwirth
RECRUITING

Saint-Priest-en-Jarez, 42271, France
Institut de Cancérologie de Lorraine
RECRUITING

Vandœuvre-lès-Nancy, 54519, France
Kantansspital Graubündern
ACTIVE_NOT_RECRUITING

Chur, 7000, Switzerland
Kantonsspital Baden
WITHDRAWN

Baden, 5404, Switzerland
Kantonsspital Baselland
WITHDRAWN

Bruderholz, 4101, Switzerland
Kantonsspital Münsterlingen
WITHDRAWN

Münsterlingen, 8596, Switzerland
Kantonsspital St.Gallen
ACTIVE_NOT_RECRUITING

Sankt Gallen, 9007, Switzerland
Klinik Hirslanden Aarau
WITHDRAWN

Aarau, 5001, Switzerland
NOVOTNA
NOT_YET_RECRUITING

Bratislava, Slovakia
Stadtspital Triemli
WITHDRAWN

Zurich, 8063, Switzerland
Studentova
NOT_YET_RECRUITING

Olomouc, Czechia

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