Gustave Roussy, Cancer Campus, Grand Paris

This large, international Phase 3 trial aims to find a better treatment for diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor with very few options. It will compare two drugs, ONC201 and everolimus, in over 430 patients, including children and adults, to …

This study is testing if adding a drug called ATRA to a precise form of radiation (SBRT) is safe and can protect a patient's immune cells from damage. The goal is to see if protecting these cells helps the body's own immune system better fight cancer that has spread to a few loca…

This study is testing an experimental drug called ASP3082 in people with advanced lung or pancreatic cancer that has a specific genetic change called KRAS G12D. The trial aims to see how well the drug works to control the cancer and to understand how the cancer might become resis…

This study is looking at how well older adults (70+) with advanced kidney cancer tolerate and respond to a standard two-drug treatment (cabozantinib and nivolumab). Researchers will closely monitor 50 patients' treatment patterns, side effects, and quality of life over time. The …

This study is testing if taking a targeted pill called olaparib for one year after finishing standard chemo and radiation can help prevent a specific, aggressive type of endometrial cancer from returning. It will compare the pill to just watching closely (observation) in over 550…

This study is testing if adding targeted radiation or surgery to standard immunotherapy helps patients with lung cancer that has spread to only a few other body sites. It will compare the standard treatment alone to the standard treatment plus these local procedures. The main goa…

This European trial is testing whether personalized treatments can help children and teenagers whose cancers have returned or not responded to standard therapies. Doctors analyze the unique genetic changes in each child's tumor and match them to specific drugs designed to target …

This study is testing a new drug called patritumab deruxtecan (U3-1402) for people with advanced breast cancer that is hormone-receptor positive and has stopped responding to standard hormone-blocking therapies and a specific type of targeted drug (CDK4/6 inhibitors). Participant…

This study is testing whether a new drug called elacestrant works as well alone as it does combined with standard ovarian suppression therapy in premenopausal women with early-stage breast cancer. Researchers will give 140 participants either the single drug or the combination fo…

This early-stage trial is testing a new therapeutic vaccine designed for people who have been treated for HPV-positive throat cancer and are currently cancer-free. The goal is to see if the vaccine is safe and can teach the body's immune system to recognize and attack any remaini…

This study is testing whether adding a targeted, internal radiation treatment called contact X-ray brachytherapy to standard chemotherapy and radiation helps more people with intermediate-stage rectal cancer avoid having their rectum surgically removed. Researchers will compare t…

This study is testing an experimental drug called tarlatamab in patients with advanced small-cell lung cancer and other aggressive neuroendocrine cancers that have worsened after standard treatments. The main goal is to see how well the drug works and to understand why some patie…

This study aims to find out if new tests using blood and other body fluids can detect cancer early in people who are at high risk of developing it. Researchers will follow nearly 6,000 high-risk participants for three years to see if these tests can spot cancers before symptoms a…

This study is testing whether a special dye that glows under near-infrared light can help surgeons see tiny leftover cancer cells during head and neck cancer surgery. The dye is injected before surgery and lights up cancer tissue, potentially helping surgeons remove more cancer i…

This study is testing if a gentle, painless laser treatment can prevent severe mouth sores in children and young adults (ages 4-25) receiving chemotherapy that is known to cause them. The laser is used preventively, before sores develop, during high-risk chemotherapy or stem cell…

This study is testing three different online support programs to help cancer patients manage the severe fatigue that often accompanies cancer and its treatment. Researchers will compare basic educational materials against more comprehensive self-help tools and programs guided by …

This study is testing whether a smartphone app can help people with early-stage breast cancer feel better while taking hormone therapy. The app provides education and self-care tips to help manage common side effects like fatigue, pain, and sleep problems. Researchers will compar…

This study is testing new integrated supportive care pathways designed to help cancer patients manage distress and improve their quality of life. Researchers will follow 700 adult patients with any type of cancer for 12 weeks to see how these care pathways affect their emotional …

This study aims to analyze the genetic makeup of cancer tumors from 20,000 adults with various cancers. Researchers will look for specific genetic changes that might be targeted by existing or future drugs. The goal is to understand which patients have these targetable changes an…

This research study aims to understand why some ovarian cancers stop responding to chemotherapy. Researchers will collect tumor samples, blood, and other fluids from 350 patients throughout their treatment journey. By analyzing these samples, they hope to find biological markers …

This study aims to create 3D models called 'immune organoids' from children's own cells to better understand how pediatric cancers interact with the immune system. Researchers will use tissue samples from up to 108 patients aged 25 or younger with brain tumors, kidney tumors, neu…