Vitamin d gel on the scalp: a new hope against chemo hair loss?

NCT ID NCT01588522

First seen Aug 17, 2026 ยท Last updated Aug 17, 2026

Summary

This early-stage trial is testing whether a topical solution containing calcitriol, a form of vitamin D, can safely reduce hair loss in adults receiving taxane-based chemotherapy for breast, gynecologic, or other solid tumors. Participants apply the solution to their scalp twice daily, starting before chemotherapy and continuing for at least three months. Researchers will monitor side effects, measure how much of the drug enters the blood, and track hair loss through photographs and diaries.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
a topical solution of calcitriol (a form of vitamin D) applied to the scalp
What this could lead to
If safe and effective, this scalp treatment could help prevent or reduce chemotherapy-induced hair loss, improving quality of life for cancer patients.
What could go wrong
This is an early-phase trial with a small number of participants, so the treatment may not work or could cause side effects. It is not yet known if it will be effective.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10022, United States

  • Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai

    Los Angeles, California, 90048, United States

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