New drug acolbifene takes on tamoxifen in breast cancer prevention trial
NCT ID NCT05941520
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether acolbifene or a low dose of tamoxifen can reduce breast cancer risk in premenopausal women at high risk. Both drugs block estrogen from reaching breast cells. Researchers will measure changes in breast tissue, blood, and mammograms over six months in 80 women.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acolbifene and tamoxifen
What this could lead to
If successful, this could point toward a new prevention option for breast cancer in high-risk premenopausal women, potentially with fewer side effects than standard tamoxifen.
What could go wrong
This is a small Phase 2 trial with only 80 participants, so results may not apply to all women. The study measures biological markers, not actual cancer rates, so it's unclear if these changes lead to fewer cancers.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact