Could a lower tamoxifen dose prevent breast cancer in high-risk women?

NCT ID NCT06184750

Recruiting now Prevention Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 7 times

Summary

This study is for premenopausal women at higher-than-average risk for breast cancer. It tests whether a low dose of tamoxifen can safely reduce breast density, which is linked to cancer risk. About 200 women will take tamoxifen, and doctors will adjust the dose if needed to get the best effect. The goal is to find a dose that works with fewer side effects.

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Conditions

The condition(s) this trial relates to.

atypical lobular breast hyperplasia breast carcinoma breast carcinoma in situ breast intraductal proliferative lesion breast neoplasm ductal breast carcinoma in situ estrogen-receptor positive breast cancer flat ductal epithelial atypia lobular breast carcinoma in situ breast cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST ATYPICAL DUCTAL HYPERPLASIA BREAST ATYPICAL LOBULAR HYPERPLASIA BREAST CARCINOMA BREAST DUCTAL CARCINOMA IN SITU BREAST LOBULAR CARCINOMA IN SITU ESTROGEN RECEPTOR-POSITIVE BREAST CARCINOMA

Contacts and locations

Locations

Brigham and Women's Hospital
WITHDRAWN

Boston, Massachusetts, 02115, United States
Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Arizona Cancer Center - Prevention Research Clinic
RECRUITING

Tucson, Arizona, 85719, United States
University of Illinois College of Medicine - Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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