EARLY-STAGE BREAST CANCER

This study aims to see if a more personalized approach improves treatment for early-stage, hormone-positive breast cancer. It will test if adding a targeted drug called a CDK4/6 inhibitor to standard hormone therapy works better for patients identified as having a higher risk of …

This study is testing if adding a targeted drug called pyrotinib to standard chemotherapy before surgery works better than chemotherapy alone for people with a specific, high-risk type of early breast cancer. It will involve about 160 adults with hormone-positive, HER2-low breast…

This study is refining a radiation technique for early-stage breast cancer where tiny, permanent radioactive seeds are implanted directly into the breast tissue. It follows 75 women for five years to improve the procedure, measure side effects, and compare costs to other radiatio…

This study is testing if starting with a lower dose of the cancer drug abemaciclib and slowly increasing it is easier for patients to tolerate than the standard full dose. It involves 90 people with early-stage, high-risk, hormone-positive breast cancer who have already had surge…

This study is testing whether giving targeted radiation to part of the breast before surgery is a safe and feasible approach for early-stage breast cancer. It will enroll about 98 patients to see if this timing leads to fewer wound problems and better cosmetic outcomes compared t…

This study is observing women with early-stage, low-risk breast cancer who receive a single dose of radiation during their lumpectomy surgery. The goal is to track how well this one-time treatment works over 5 to 10 years, including cancer recurrence rates and side effects. It al…

This study aims to understand how standard hormone-blocking treatments affect the quality of life of premenopausal women with early-stage breast cancer. Researchers will follow 450 women in Italy who are already receiving these treatments, tracking their well-being, hormone level…