EARLY STAGE BREAST CANCER

This study tests whether giving a short course of radiation to the tumor area before surgery is safe and practical for women with early-stage breast cancer. About 98 women over age 50 with small, low-grade tumors will receive radiation, then have surgery. Researchers will check w…

This study looks at whether adding a targeted drug (CDK4/6 inhibitor) to standard hormone therapy before surgery can improve outcomes for women with a specific type of early-stage breast cancer (HR+/HER2-). Researchers will use a genetic test and early changes in a cell growth ma…

This study compares a 1-week radiation schedule to the standard 3-week schedule for people with early-stage breast cancer who had lumpectomy. The goal is to see if the shorter treatment controls cancer just as well while causing fewer side effects. About 72 adults with non-invasi…

This study looks at a type of radiation therapy for early-stage breast cancer where tiny radioactive seeds are placed directly into the breast after a lumpectomy. The goal is to improve the technique and see how well patients tolerate it, as well as compare costs with other radia…

This study tests whether adding the targeted drug pyrotinib to standard chemotherapy can improve outcomes for people with a specific type of early breast cancer (HR-positive, HER2-low). About 160 participants will receive either the combination or chemotherapy alone before surger…

This study tests whether slowly increasing the dose of the drug abemaciclib can cause fewer side effects than the standard dose in people with early-stage, hormone receptor-positive breast cancer. About 90 participants will take the drug along with standard hormone therapy. The g…

This study tests a portable cooling cap (AMMA) worn during chemotherapy to prevent hair loss in women with early-stage breast cancer. About 40 women receiving specific chemo drugs will use the cap. The goal is to see if the cap keeps hair loss mild (Grade 2 or less) and safe.

This study is a registry that follows women aged 50 and older with early-stage, low-risk breast cancer who receive a single dose of radiation during their lumpectomy surgery (IORT). The goal is to track how often the cancer comes back and monitor side effects, quality of life, an…

This study follows 450 premenopausal women with early-stage, hormone-sensitive breast cancer in Italy. Researchers want to see how adding the drug triptorelin to standard hormone therapy affects quality of life and hormone levels. The goal is to better understand the real-world i…