Heart shield: statins may keep cancer therapy on track

NCT ID NCT05559164

Recruiting now Disease control Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking a daily statin (atorvastatin) can prevent heart damage caused by HER2-targeted therapy in women with early-stage breast cancer. About 60 participants will take the statin alongside their cancer treatment. The goal is to reduce treatment delays or early stops due to heart problems, helping patients complete their full cancer therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atorvastatin (Lipitor) 40 mg tablet
What this could lead to: If it works, this could show that taking a common statin alongside HER2 therapy helps protect the heart, allowing more patients to complete their cancer treatment without delays.
What could go wrong: This is a small Phase 2 trial with only 60 participants, so results may not apply to everyone. Statins have side effects like muscle pain, and the heart benefit is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Cardiotoxicity HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC TOXICITY EARLY-STAGE BREAST CANCER

Contacts and locations

Locations

Monmouth Community Medical
RECRUITING

Long Branch, New Jersey, 07764, United States
Monmouth Medical Center Southern Campus
RECRUITING

Lakewood, New Jersey, 08701, United States
RWJBarnabas Health - - Jersey City Medical Medical
RECRUITING

Jersey City, New Jersey, 07097, United States
RWJBarnabas Health - Monmouth Medical Center
RECRUITING

Long Branch, New Jersey, 07740, United States
RWJBarnabas Health - Newark Beth Israel Medical Center
RECRUITING

Newark, New Jersey, 07112, United States
RWJBarnabas Health - Robert Wood Johnson University Hospital
NOT_YET_RECRUITING

New Brunswick, New Jersey, 08903, United States
RWJBarnabas Health - Robert Wood Johnson University Hospital
RECRUITING

Somerset, New Jersey, 08873, United States
RWJBarnabas Health - Robert Wood Johnson University Hospital, Hamilton
RECRUITING

Hamilton, New Jersey, 08690, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Trinitas Hospital and Comprehensive Cancer Center
RECRUITING

Elizabeth, New Jersey, 07202, United States

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