Can a short, High-Dose radiation blast before surgery improve breast cancer care?
NCT ID NCT04360330
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial is testing a new way to deliver radiation therapy for early-stage breast cancer. Instead of the usual weeks of daily radiation after surgery, this approach gives a shorter, more intense course of radiation before the tumor is removed. The study aims to find the safest and most effective dose of this preoperative radiation, called SABER, in women aged 50 and older with a specific type of early-stage breast cancer. By giving radiation before surgery, doctors hope to potentially improve treatment outcomes and reduce the overall treatment time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Stereotactic Ablative Breast Radiotherapy (SABER)
- What this could lead to
- If successful, this could lead to a shorter, more effective radiation treatment before surgery for early-stage breast cancer, potentially improving outcomes and reducing side effects.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the optimal dose and safety profile are still being determined. There is a risk of radiation-related side effects, and the approach may not prove better than standard care.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Miami
RECRUITINGMiami, Florida, 33136, United States
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