Bone pain breakthrough? trial tests skipping G-CSF during chemo

NCT ID NCT05753618

Recruiting now Symptom relief Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This trial tests whether women with early-stage breast cancer can safely skip a drug called G-CSF during part of their chemotherapy to reduce bone pain. About 242 participants will either receive or skip G-CSF after paclitaxel infusions. The main goal is to see if skipping it lowers pain without causing serious infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Granulocyte colony-stimulating factor (G-CSF) (filgrastim or pegfilgrastim)
What this could lead to: If successful, this could show that many patients can safely skip G-CSF during paclitaxel chemo, reducing bone pain and simplifying treatment.
What could go wrong: This is a small, early-phase trial focused on pain, not on infection rates or cancer outcomes. Skipping G-CSF might increase the risk of febrile neutropenia in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY-STAGE BREAST CANCER

Contacts and locations

Locations

Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
Lakeridge Health
RECRUITING

Oshawa, Ontario, L1G 2B9, Canada
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada

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