Ottawa Hospital Research Institute

This pilot trial tests whether giving the immunosuppressant drug mycophenolate mofetil (MMF) for six months after a stem cell transplant can prevent systemic sclerosis from relapsing. Six adults with scleroderma who are undergoing a stem cell transplant will take MMF starting 90 …

This trial asks whether giving blood transfusions to keep hemoglobin levels higher (90-100 g/L) during and right after major surgery reduces serious complications or death within 30 days, compared to a lower threshold (70-80 g/L). About 5,000 adults at risk of needing a transfusi…

This study tests whether a best-practices checklist can help emergency doctors manage acute heart failure more effectively. The checklist guides assessment, treatment, and decisions about whether to admit or discharge patients. Researchers are introducing the checklist in four la…

This study explores whether measuring a hormone called renin can help doctors choose the best first medication for people with early-stage high blood pressure. Adults with low renin levels are randomly assigned to receive either spironolactone or a standard blood pressure drug fo…

This trial investigates whether adding bacteriophages—viruses that specifically target and kill bacteria—to standard surgery and antibiotics can improve outcomes for people with infected hip or knee replacements. The study enrolls adults with an infection caused by Staphylococcus…

This trial tests a home-based program of exercise, breathing exercises, nutrition advice, and emotional support for people waiting for a kidney transplant. Participants start the program at least 4 weeks before surgery and continue for 18 weeks after leaving the hospital. The goa…

This study tests whether the powder used to clean the bowel before a colonoscopy can be taken as vegan capsules instead of mixing it into a liquid drink. Adults aged 18 to 75 who have had a prior colonoscopy will swallow many capsules with clear fluids. Researchers will check if …

Cellulitis is a painful bacterial skin infection. This study tests whether adding naproxen (an anti-inflammatory drug) to standard antibiotics helps reduce redness and pain faster than antibiotics alone. About 884 adults with cellulitis will take either naproxen or a placebo for …

This study tests whether a combination of anti-nausea drugs (netupitant/palonosetron) can effectively prevent nausea and vomiting in people with germ cell cancer receiving multi-day cisplatin chemotherapy, while using fewer steroids than usual. Ten participants will be randomly a…

This pilot study tests whether a coach-supported, online brain training program before elective surgery can help older adults recover their thinking skills faster. Researchers will enroll 103 people aged 60 and older who are waiting for surgery. The main goal is to see if partici…

This study follows 700 cancer patients who take blood thinners and are scheduled for surgery or medical procedures. Researchers will track how often major bleeding or clotting events occur within 30 days after the procedure. The goal is to see if current blood thinner management …