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Blood pressure breakthrough? Renin-Guided therapy may offer smarter First-Line treatment

NCT ID NCT07687160

Not yet recruiting Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study explores whether measuring a hormone called renin can help doctors choose the best first medication for people with early-stage high blood pressure. Adults with low renin levels are randomly assigned to receive either spironolactone or a standard blood pressure drug for 12 weeks. The goal is to see if this renin-guided strategy is practical in primary care and whether spironolactone leads to better blood pressure control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Spironolactone
What this could lead to
If successful, this approach could offer a more personalized, effective first-line treatment for people with low-renin hypertension, potentially reducing cardiovascular risk.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply broadly. Spironolactone can cause side effects like high potassium or kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

early onset hypertension hyperaldosteronism hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY-STAGE HYPERTENSION AND SUPPRESSED RENIN HYPERTENSION

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ottawa Nurse Practitioner-Led Clinic

    Ottawa, Ontario, K1L 8L8, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • St-Isidore Médical

    Saint Isidore, Ontario, K0C 2B0, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Ottawa Hospital

    Ottawa, Ontario, K1H 7W9, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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